Bacillus coagulans preparation for treating depression
A technology for Bacillus coagulans and depression, which is applied to Bacillus coagulans and polypeptides in the field of preparation of preparations for preventing or treating depression, can solve the problem of being difficult to achieve the same effect of antidepressants, and achieve the effects of increasing BDNF content and improving depression symptoms
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Embodiment 1
[0016] Example 1: Effect experiment on BDNF content in the brain tissue of chronic unpredictable stress model rats
[0017] The nutritive polypeptide of the present invention is chemically synthesized by a laboratory using a solid-phase synthesis method, and its sequence is verified.
[0018] Taking SD rats as test animals, 84 rats were taken, half male and half female, weighing 200-220 g, and randomly divided into 6 groups, including model group and experimental group 1-5. Each group was given the same food and feed, and the experiment was carried out under the same feeding conditions; Bacillus coagulans, fluoxetine and polypeptide were all formulated into solutions with 0.9% physiological saline.
[0019] Referring to the patented method, establish a chronic unpredictable stress model in rats: fasting for 24 hours, water deprivation for 24 hours, tail clamping for 5 minutes, day and night reversal for 24 hours, swimming in cold water at 4°C for 5 minutes, environment at 45°C...
Embodiment 2
[0023] Example 2: Observation of Behavioral Changes in Depression Model Rats
[0024] Animal models were established according to the same method as in Example 1, and treatment experiments were carried out.
[0025] Dosing regimen: prepare drugs with corresponding concentrations as shown in the table below, and give each rat 1ml of the drug by gavage every day, and the blank group is given normal saline; all drugs are given continuously for 7 days. One hour after administration on the seventh day, behavioral evaluations were performed, including forced swimming test and sugar water preference test. Data were statistically analyzed using SPSS 21.0.
[0026] The experimental scheme and results are shown in the table below:
[0027]
[0028]
[0029] The experimental results are as shown in the table, Bacillus coagulans has almost no influence on the forced swimming time of rats, although the polypeptide of the present invention can play a similar effect to fluoxetine; th...
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