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Bacillus coagulans preparation for treating depression

A technology for Bacillus coagulans and depression, which is applied to Bacillus coagulans and polypeptides in the field of preparation of preparations for preventing or treating depression, can solve the problem of being difficult to achieve the same effect of antidepressants, and achieve the effects of increasing BDNF content and improving depression symptoms

Active Publication Date: 2021-07-30
天津市宝恒生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is difficult to achieve the same effect as traditional antidepressants with only probiotic preparations

Method used

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  • Bacillus coagulans preparation for treating depression
  • Bacillus coagulans preparation for treating depression
  • Bacillus coagulans preparation for treating depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1: Effect experiment on BDNF content in the brain tissue of chronic unpredictable stress model rats

[0017] The nutritive polypeptide of the present invention is chemically synthesized by a laboratory using a solid-phase synthesis method, and its sequence is verified.

[0018] Taking SD rats as test animals, 84 rats were taken, half male and half female, weighing 200-220 g, and randomly divided into 6 groups, including model group and experimental group 1-5. Each group was given the same food and feed, and the experiment was carried out under the same feeding conditions; Bacillus coagulans, fluoxetine and polypeptide were all formulated into solutions with 0.9% physiological saline.

[0019] Referring to the patented method, establish a chronic unpredictable stress model in rats: fasting for 24 hours, water deprivation for 24 hours, tail clamping for 5 minutes, day and night reversal for 24 hours, swimming in cold water at 4°C for 5 minutes, environment at 45°C...

Embodiment 2

[0023] Example 2: Observation of Behavioral Changes in Depression Model Rats

[0024] Animal models were established according to the same method as in Example 1, and treatment experiments were carried out.

[0025] Dosing regimen: prepare drugs with corresponding concentrations as shown in the table below, and give each rat 1ml of the drug by gavage every day, and the blank group is given normal saline; all drugs are given continuously for 7 days. One hour after administration on the seventh day, behavioral evaluations were performed, including forced swimming test and sugar water preference test. Data were statistically analyzed using SPSS 21.0.

[0026] The experimental scheme and results are shown in the table below:

[0027]

[0028]

[0029] The experimental results are as shown in the table, Bacillus coagulans has almost no influence on the forced swimming time of rats, although the polypeptide of the present invention can play a similar effect to fluoxetine; th...

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Abstract

The invention provides a pharmaceutical composition for treating depression. The composition comprises bacillus coagulans and a nutritional polypeptide, wherein the pharmaceutical composition provided by the invention can up-regulate the level of brain-derived neurotrophic factors and improve the depressive symptom of depression model animals. The pharmaceutical composition provided by the invention can be used as an effective candidate therapeutic drug for clinical treatment of depression, and has potential drug development value.

Description

Technical field: [0001] The invention relates to the application of the bacillus coagulans and the polypeptide in the preparation of preparations for preventing or treating depression, in particular the use of the bacillus coagulans and the antidepressant polypeptide to reduce depression symptoms. Background technique: [0002] Depression is the most common depressive disorder, with significant and persistent low mood as the main clinical feature, and it is the main type of mood disorders. It can be seen clinically that the mood is not commensurate with the situation. The depression of mood can range from gloomy to distraught, low self-esteem and depression, even pessimistic world-weariness, and there may be suicide attempts or behaviors; even stupor; some cases have obvious anxiety and motor agitation; In severe cases, psychotic symptoms such as hallucinations and delusions may appear. Each attack lasts for at least 2 weeks, or even several years in the elderly. Most cases...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/16A61K35/742A61P25/24
CPCA61K38/16A61K35/742A61P25/24A61K2300/00
Inventor 李宝恒李倩舒威
Owner 天津市宝恒生物科技有限公司
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