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Application of liquiritin in preparation of medicine for treating or preventing enterovirus 71 infection

A technology of enterovirus and liquiritin, which is applied in antiviral agents, pharmaceutical formulas, and medical preparations containing active ingredients, etc., can solve the problems of restricting safe and effective treatment, unclear antiviral or neuroprotective mechanism, central nervous system damage and other issues

Active Publication Date: 2021-11-12
ZUNYI MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the pathogenesis of central nervous system damage caused by EV71 infection, as well as the antiviral or neuroprotective mechanism of traditional Chinese medicine or natural products are still unclear, which is still a bottleneck restricting its safe and effective treatment.

Method used

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  • Application of liquiritin in preparation of medicine for treating or preventing enterovirus 71 infection
  • Application of liquiritin in preparation of medicine for treating or preventing enterovirus 71 infection
  • Application of liquiritin in preparation of medicine for treating or preventing enterovirus 71 infection

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Experimental program
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Embodiment Construction

[0014] The following is further described in detail through specific implementation methods:

[0015] 1. Establish EV71-infected suckling mouse model, and observe the therapeutic effect of liquiritin on EV71-infected suckling mice

[0016] 1.1 Modeling method

[0017] Thirty 3-day-old ICR suckling mice, weighing 3±0.5g, were divided into 3 groups, 10 in each group, respectively: ① blank control group (Control group); ② model group (EV71 group); ③ liquiritin treatment group ( LQ group). Model group and liquiritin treatment group were given intracranial injection of 50 μL of EV71 virus stock solution to prepare EV71 infection model, and the blank control group was given intracranial injection of the same amount of normal saline. On the second day after modeling, the liquiritin treatment group was given liquiritin 0.06 mg / g orally, once a day, for 5 days in total. The blank control group and the model group were given the same dose of normal saline by intragastric administrati...

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Abstract

The invention discloses an application of liquiritin in preparation of a medicine for treating or preventing enterovirus 71 infection and an application of liquiritin in preparation of a medicine for inhibiting enterovirus 71 replication, and belongs to the technical field of traditional Chinese medicine pharmacy. Research finds that after the liquiritin is adopted for intragastric administration, the expression quantity of EV71VP1 in brain tissue can be reduced, the inflammatory factor IL-6 can be reduced, and virus replication is inhibited, so that the neurological symptom of the hand-foot-and-mouth disease caused by EV71 is improved.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine pharmacy, and relates to the application of liquiritin in the preparation of antiviral drugs, in particular to the application of liquiritin in the preparation of drugs for treating or preventing enterovirus 71 infection. Background technique [0002] Enterovirus 71 (enterovirus71, EV71) infection has become a major threat to global public health, especially in infants and young children. Epidemiological studies have shown that EV71 infection is the main cause of severe and even fatal HFMD. EV71 infection is usually accompanied by severe neurological complications such as aseptic meningitis, acute flaccid paralysis, encephalitis, etc. These neurological complications and neurogenic pulmonary edema are considered to be the main disease process in fatal cases. For the central nervous system diseases caused by EV71 infection, there are no effective antiviral drugs and clinically...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P31/14
CPCA61K31/7048A61P31/14Y02A50/30
Inventor 李晋徐尚福杜文琪
Owner ZUNYI MEDICAL UNIVERSITY
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