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Method for setting tolerance limit value for monitoring intensity modulated radiation therapy dose verification process

An intensity-modulated radiation therapy and dose verification technology, applied in radiation therapy, X-ray/γ-ray/particle irradiation therapy, treatment, etc., can solve problems such as unreliability, increased false alarm rate, wrong decision-making, etc., and reaches the tolerance limit Robustness, reduced workload, good performance effects

Active Publication Date: 2021-11-12
WEST CHINA HOSPITAL SICHUAN UNIV
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Problems solved by technology

[0005] However, the conventional Shewhart control chart is established based on the observations conforming to the normal distribution. A large number of studies in the field of statistical process control have confirmed that it is unreliable to directly use the conventional Shewhart control chart method to establish control limits for non-normal processes. , will increase the probability of making a type I error, leading to wrong decisions
Recent studies have also shown that most of the gamma pass rates do not satisfy the normal distribution, and directly using the Shewhart control chart method to calculate the control limit of the non-normal intensity-modulated radiotherapy dose verification process will overestimate the actual tolerance limit and increase False positive rate, increasing workload for radiotherapy physicists investigating "problem" programs

Method used

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  • Method for setting tolerance limit value for monitoring intensity modulated radiation therapy dose verification process
  • Method for setting tolerance limit value for monitoring intensity modulated radiation therapy dose verification process
  • Method for setting tolerance limit value for monitoring intensity modulated radiation therapy dose verification process

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Effect test

Embodiment 1

[0051] Embodiment 1: A method for setting the tolerance limit of the intensity-modulated radiotherapy dose verification process

[0052] Step 1. Select a certain number of IMRT plans

[0053] The intensity-modulated radiotherapy plan used in this example is a VMAT plan for 586 cases, including 49 cases of brain tumors, 129 cases of nasopharyngeal cancer, 39 cases of cervical cancer, 39 cases of prostate cancer, and 110 cases of rectal cancer. A total of 220 cases of diseases.

[0054] Step 2. Dose measurement on the accelerator using a two-dimensional or three-dimensional detector array dedicated to dose verification

[0055] The detector array selected in this embodiment is the three-dimensional detector array ArcCHECK. Align ArcCHECK with the laser light before measurement, perform matrix calibration, background calibration, and dose calibration on the ArcCHECK phantom according to the standard steps provided by SunNuclear; use the patient’s VMAT plan to perform beam outpu...

experiment example 1

[0080] Experimental Example 1: Using the tolerance limit set by the present invention to detect the reliability of the dose verification process of the intensity-modulated radiotherapy plan

[0081] 1. Experimental method

[0082] Use the method of Example 1 of the present invention and the conventional Shewhart control chart method recommended in the AAPM TG-218 report to set the tolerance limit, and compare the reliability of the tolerance limit obtained by the two methods.

[0083]1) Utilize the method of Embodiment 1 of the present invention to establish the tolerance limits of the dose verification process

[0084] A total of 586 cases of VMAT plan dose verification have been implemented, including 49 cases of brain tumors, 129 cases of nasopharyngeal cancer, 39 cases of cervical cancer, 39 cases of prostate cancer, 110 cases of rectal cancer, and a total of 220 cases of other diseases with a planned number of less than 25 cases example. The tolerance limits of the whol...

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Abstract

The invention provides a method for setting a tolerance limit value for monitoring an intensity modulated radiation therapy dose verification process, and belongs to the field of intensity modulated radiation therapy dose verification. The method is insensitive to the distribution of the gamma passing rate in the intensity modulated radiation therapy dose verification process, so that the influence of non-normality on control limit value calculation is reduced. Therefore, the tolerance limit value obtained through the method is more stable and reliable. The tolerance limit value obtained based on the method has good performance in monitoring the intensity modulated radiation therapy dose verification process; an intensity modulated radiation therapy plan with the out-of-control problem can be effectively detected, and in addition, the workload of a radiation therapy physicist for investigating the "problem" plan is reduced.

Description

technical field [0001] The invention belongs to the field of dose verification of intensity-modulated radiotherapy, and in particular relates to a method for setting a tolerance limit value for monitoring the dose verification process of intensity-modulated radiotherapy. Background technique [0002] In modern radiation therapy, dynamic delivery techniques such as intensity-modulated radiation therapy (IMRT) and volumetric modulation-modulated radiation therapy (VMAT) have become standard treatment techniques in many radiation therapy centers. Among them, the intensity-modulated radiotherapy technology can realize the optimal dose distribution of the target area through height modulation, and at the same time minimize the irradiation dose to surrounding normal tissues and organs at risk, thereby further reducing the occurrence of toxic and side effects while ensuring the curative effect. [0003] With the increase in the complexity of treatment equipment and techniques, comp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N5/10
CPCA61N5/1048A61N5/1071A61N2005/1074
Inventor 肖青李光俊白龙段炼柏森
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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