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Application of frontal bone mesenchymal stem cells in treatment and/or prevention of animal traumatic brain injury

A mesenchymal stem cell and invasive technology, applied in the field of biomedicine, can solve problems such as no treatment method and complicated TBI

Pending Publication Date: 2022-01-18
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the complexity and heterogeneity of TBI, despite intensive research, there is no effective treatment to date

Method used

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  • Application of frontal bone mesenchymal stem cells in treatment and/or prevention of animal traumatic brain injury
  • Application of frontal bone mesenchymal stem cells in treatment and/or prevention of animal traumatic brain injury
  • Application of frontal bone mesenchymal stem cells in treatment and/or prevention of animal traumatic brain injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1. Frontal bone MSCs can promote nerve repair after TBI

[0039] 1. Gene chip

[0040] The frontal bone MSCs and bone marrow MSCs derived from mice were cultured respectively, and enough cells were collected, and samples were sent to Shanghai Ouyi Technology Biological Co., Ltd. for subsequent extraction and analysis. The gene expression of frontal bone MSCs and bone marrow MSCs was significantly different by gene chip analysis. Frontal bone MSCs highly expressed ectodermal marker Tfap2β and growth factor FGF1, indicating that frontal bone MSCs and bone marrow MSCs have different sources, and ectoderm has advantages in treating neurological diseases. There are also significant differences between frontal bone MSCs and bone marrow MSCs in neural ligand-receptor pathway and TNF-α pathway, as well as in biological processes such as neural differentiation and inflammatory response. figure 1 .

[0041] 2. Animals

[0042] Mice: C57BL / 6 mice, Weitong Lihua, aged 8...

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Abstract

The invention discloses application of frontal bone mesenchymal stem cells in treatment and / or prevention of animal traumatic brain injury. The invention discovers that the frontal bone-derived MSC can improve the neuroinflammation microenvironment of an injured area, reduce activation of astrocytes and microglia, promote neuronal synaptic remodeling and promote nerve repair after TBI, so that persistent injury caused by TBI and neurological dysfunction caused by the persistent injury are relieved, and new seed cells are provided for treatment of TBI. The application has a good application prospect.

Description

technical field [0001] The invention relates to the application of frontal bone mesenchymal stem cells in the treatment and / or prevention of animal traumatic brain injury in the field of biomedicine. Background technique [0002] Traumatic brain injury (TBI) is a global public health problem with limited treatment options. Traumatic brain injury (TBI) is a leading cause of mortality and morbidity worldwide. Survivors may suffer from cognitive and memory deficits, vision and hearing loss, movement disorders and different psychological problems. The main pathological changes of brain injury include the loss of normal tissue structure, the destruction of neurons and the disorder of the internal environment, among which neuron damage is one of the most important pathological changes. Due to the complexity and heterogeneity of TBI, despite intensive research, there is no effective treatment to date. [0003] TBI causes primary injury at the time of onset, followed by secondary...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/28A61P25/00A61P25/28A61P29/00
CPCA61K35/28A61P25/00A61P25/28A61P29/00
Inventor 江小霞王妍王长振秦巧臻张鹤扬徐振华刘水蓉杜张珍
Owner ACADEMY OF MILITARY MEDICAL SCI
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