Apparatus and method for enhancing the dissolution rate of drugs for the treatment of parasitic infections

Abstract

The invention discloses a device and method for improving the dissolution rate of drugs for treating parasitic infections in the technical field of drug dissolution. The device for improving the dissolution rate of drugs for treating parasitic infections includes a processing cylinder, and the inner side of the processing cylinder is fixedly connected with Centrifugal separation membrane, the inside of the treatment cylinder is connected with a sealing mechanism for supporting and sealing the centrifugal separation membrane during the dilution and mixing process; the present invention utilizes the mutual cooperation of the sealing mechanism and the stirring mechanism in each process of preparing microcrystalline cellulose, so that The microcrystalline cellulose solution is layered more thoroughly, and with the separation mechanism, the microcrystalline cellulose can be separated and precipitated in time without retrieving materials, which avoids the loss of the collected microcrystalline cellulose during the retrieving process, thereby improving the quality of the microcrystalline cellulose. The separation effect of cellulose, thereby improving the dissolution rate of drugs for the treatment of parasitic infections.

Description

technical field [0001] The invention relates to the technical field of drug dissolution, in particular to a device and method for improving the drug dissolution for treating parasitic infections. Background technique [0002] Microcrystalline cellulose is a hydrolyzed product of natural cellulose, with a white or off-white appearance. It is a crystalline powder product, insoluble in water, stable in nature, and does not chemically react with the main drug. As a filler, it can be used in a proper amount in the prescription, which can make the prepared particles loose, uniform and fine, and have good binding performance. At the same time, it is also a good disintegrant because it can rapidly expand the tablet and disintegrate after absorbing water. [0003] In the pharmaceutical industry, microcrystalline cellulose is widely used in pharmaceutical preparations, and microcrystalline cellulose is often used as an adsorbent, suspending agent, diluent, and disintegrating agent. ...

AI Technical Summary

Problems solved by technology

[0008] The object of the present invention is to provide a device and method for improving the dissolution rate of drugs for treating parasitic infections, so as to solve the above-mentioned background technology that the difference in element content in microcrystalline cellulose will greatly affect the drug dissolution rate, and the existing In the process of preparing A-type microcrystalline cellulose in the technology, the separation of microcrystalline cellulose is not complete. When sampling after dispersion, dilution and stratification, it is easy to cause the elements in the top layer to mix with the elements in the bottom layer, resulting in the separation of microcrystalline cellulose. There is an error in the composition of crystalline cellulose, and the loss of microcrystalline cellulose is likely to be caused during the sampling process, which eventually leads to the problem of a decrease in the dissolution rate of microcrystalline cellulose

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