Device and method for improving dissolution rate of medicine for treating parasitic infection

Abstract

The invention discloses a device and a method for improving the dissolution rate of a medicine for treating parasitic infection, and belongs to the technical field of medicine dissolution. The device for improving the dissolution rate of the medicine for treating the parasitic infection comprises a treatment cylinder, and a centrifugal separation membrane is fixedly connected to the inner side of the treatment cylinder; the inner side of the treatment cylinder is connected with a sealing mechanism for supporting and sealing the centrifugal separation membrane in the diluting and mixing process; in each microcrystalline cellulose preparation process, the sealing mechanism and the stirring mechanism are matched with each other, so that a microcrystalline cellulose solution is layered more thoroughly, the microcrystalline cellulose is separated and separated out in time in cooperation with the separation mechanism, material taking is not needed, loss of the microcrystalline cellulose collected in the material taking process is avoided, and thus the separation effect of microcrystalline cellulose is improved, and the dissolution rate of drugs for treating parasitic infection is further improved.

Description

technical field [0001] The invention relates to the technical field of drug dissolution, in particular to a device and method for improving the drug dissolution for treating parasitic infections. Background technique [0002] Microcrystalline cellulose is a hydrolyzed product of natural cellulose, with a white or off-white appearance. It is a crystalline powder product, insoluble in water, stable in nature, and does not chemically react with the main drug. As a filler, it can be used in a proper amount in the prescription, which can make the prepared particles loose, uniform and fine, and have good binding performance. At the same time, it is also a good disintegrant because it can rapidly expand the tablet and disintegrate after absorbing water. [0003] In the pharmaceutical industry, microcrystalline cellulose is widely used in pharmaceutical preparations, and microcrystalline cellulose is often used as an adsorbent, suspending agent, diluent, and disintegrating agent. ...

AI Technical Summary

Problems solved by technology

[0008] The object of the present invention is to provide a device and method for improving the dissolution rate of drugs for treating parasitic infections, so as to solve the above-mentioned background technology that the difference in element content in microcrystalline cellulose will greatly affect the drug dissolution rate, and the existing In the process of preparing A-type microcrystalline cellulose in the technology, the separation of microcrystalline cellulose is not complete. When sampling after melt dilution and stratification, it is easy to cause the elements in the top layer to mix with the elements in the bottom layer, resulting in the separation of microcrystalline cellulose. There is an error in the composition of crystalline cellulose, and the loss of microcrystalline cellulose is likely to be caused during the sampling process, which eventually leads to the problem of a decrease in the dissolution rate of microcrystalline cellulose

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