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Formulations for odontological and dermatological use containing trichloroacetate salts and hydroxyacids

A trichloroacetate, dental technology, applied in skin care preparations, medical preparations containing active ingredients, skin diseases, etc., can solve problems such as patient-related life restrictions

Pending Publication Date: 2022-02-25
GPQ SRL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this case, the postoperative recovery period may limit the patient's relative life

Method used

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  • Formulations for odontological and dermatological use containing trichloroacetate salts and hydroxyacids
  • Formulations for odontological and dermatological use containing trichloroacetate salts and hydroxyacids
  • Formulations for odontological and dermatological use containing trichloroacetate salts and hydroxyacids

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] To a 49.8% w / w aqueous solution of ammonium trichloroacetate (66.3 Kg) was added under stirring at 20-25°C 25 kg of an aqueous solution having the following composition: tartaric acid (1 Kg), citric acid (4 Kg), deionized water (20Kg). Then 50% w / w phytic acid aqueous solution (400g), 30% hydrogen peroxide (3.3Kg), deionized water (4.4Kg), (600 g) were sequentially added (within 30') to the resulting solution in portions. The resulting mixture was then maintained under stirring at room temperature to obtain a homogeneous solution, which was then filtered on a suitable 10 micron filter. The pH of the resulting solution is comprised in the range of 1.8-2.2.

[0045] The final composition of the formulation

[0046]

Embodiment 2

[0048] Add homocysteine ​​(2.0Kg), 50% w / w aqueous solution of tartaric acid (2.0kg), citric acid (4.0Kg), deionized water (25.6Kg) sequentially under stirring at 20-25°C to 50.2% w / w ammonium trichloroacetate in water (65.8 Kg). Hydroxyethylcellulose (600 g) was then added portionwise (within 30') to the resulting solution. The resulting solution was then maintained under stirring at room temperature for 60' and then filtered on a suitable 10 micron filter. The pH of the resulting solution is comprised in the range of 1.8-2.2.

[0049] The final composition of the formulation

[0050] components quantity Composition (weight%) Deionized water 59.4Kg 59.4％ tartaric acid 1.0Kg 1.0％ Homocysteine 2.0Kg 2.0％ citric acid 4.0Kg 4.0％ Ammonium trichloroacetate 33.0Kg 33.0％ Hydroxyethyl cellulose 0.6Kg 0.6％

Embodiment 3

[0052] Homocysteine ​​(2.0Kg), 50% w / w aqueous solution of tartaric acid (2.0kg), citric acid (4.0Kg), trichloroacetic acid (11.0Kg), deionized Water (14.6 Kg) was sequentially added to a 50.2% w / w aqueous solution of ammonium trichloroacetate (65.8 Kg). Hydroxyethylcellulose (600 g) was then added portionwise (within 30') to the resulting solution at room temperature with stirring. The resulting solution was then maintained under stirring at room temperature for 60' before being filtered on a suitable 10 micron filter. The pH of the resulting solution is comprised in the range of 1.8-1.2.

[0053] The final composition of the formulation

[0054] components quantity Composition (weight%) Deionized water 48.4Kg 48.4％ tartaric acid 1.0Kg 1.0％ Homocysteine 2.0Kg 2.0％ citric acid 4.0Kg 4.0％ Ammonium trichloroacetate 33.0Kg 33.0％ trichloroacetic acid 11.0Kg 11.0％ Hydroxyethyl cellulose 0.6Kg 0.6％

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Abstract

Pharmaceutical, odontological, cosmetic and dermatological compositions comprising addition salts of trichloroacetic acid, one or more hydroxyacids and optionally glutamic acid or glutamic acid bioisosteres and phytic acid are useful for the peeling of the gingival collar, skin peeling, for resurfacing, treating skin hyper pigmentation, control sebum production, acne, pore size reduction and reducing the appearance of scars without causing undesirable side effects and contrast in coloration of the treated skin, for stimulation of the fibroblasts, transdermal biorevitalization, stimulation of the production of new collagen, for aesthetic improvement, for skin lightening, skin beautifying, skin firming and skin rejuvenation.

Description

[0001] field of invention [0002] The present invention relates to compositions for pharmaceutical, dental, cosmetic and dermatological use, in particular for gingival collar peeling, skin peeling, and for resurfacing, treatment of skin hyperpigmentation, control of Sebum production, used in the treatment of acne, used to reduce pore size and reduce the appearance of scarring without adverse side effects such as frosting, scarring, infection, recurrence of herpes simplex infection and color contrast of treated skin, used to stimulate Fibroblasts, transdermal bioregeneration, stimulation of new collagen production, for improving aesthetics, for skin brightening, skin beautification, skin firming and skin regeneration. These novel formulations containing addition salts of trichloroacetic acid exhibit antibacterial properties, and induce stratum corneum desquamation, stimulating skin cells to form new collagen. [0003] technical background [0004] It is known that the stratum ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/34A61K9/08A61K8/365A61K8/44A61K31/047A61K8/55A61K31/19A61K31/198A61P17/00A61K31/6615A61K8/46A61Q19/08A61K8/36
CPCA61K8/345A61K9/08A61K9/0014A61K8/365A61K8/44A61K31/047A61K8/55A61K31/19A61K31/198A61P17/00A61K31/6615A61K8/466A61Q19/08A61K8/36A61K2300/00A61K9/06A61K9/006A61K47/12A61K47/38A61K47/02A61K31/194A61P17/10A61P1/02A61K8/19A61K8/731
Inventor 罗萨纳·卡斯特拉纳
Owner GPQ SRL
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