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Soluble microneedle and medicine feeding device

A soluble and microneedle technology, which is applied in the direction of microneedles, needles, and medical devices, can solve the problems of inapplicable rapid decomposition and increase the sustained release time, so as to reduce liver organ damage and economic burden, reduce scars, The effect of shortening the dark period

Active Publication Date: 2022-03-18
BEIJING INSTITUTE OF TECHNOLOGYGY
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  • Summary
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  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

However, the current soluble microneedles that are not specially used for photosensitizers are mostly designed to increase the sustained release time. It is hoped that the drug contained in the microneedles can increase the sustained release time in the skin, which is not suitable for photodynamic therapy. Decomposition requirements

Method used

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  • Soluble microneedle and medicine feeding device
  • Soluble microneedle and medicine feeding device
  • Soluble microneedle and medicine feeding device

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Embodiment Construction

[0022] The present invention will be described in further detail below in conjunction with the accompanying drawings and examples. Here, the exemplary embodiments of the present invention and their descriptions are used to explain the present invention, but not to limit the present invention.

[0023] A dissolvable solid microneedle and drug feeding device for photodynamic therapy of the present invention, specifically:

[0024] Solid microneedles are composed of soluble biological tissue materials (such as sodium hyaluronate, polylactic acid), and a certain concentration of photodynamic therapy pharmaceutical preparations (such as 1% concentration of photosensitizer hemporfin, ALA5) are added according to the therapeutic dose. Mold, vacuum, and dry to form a soluble solid with hardness. Such as figure 1 and 2 As shown, the microneedle mainly includes two sections of the tip part 102 and the base part 101, and the middle part between the tip part and the base part can be re...

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Abstract

According to the soluble solid microneedle for photodynamic therapy and the medicine feeding therapy device, a photodynamic therapeutic agent and inherent components (glucuronic acid and polylactic acid) of a human body are mixed according to a certain proportion to form a microneedle array capable of puncturing the skin, and the microneedle can be injected to the specific depth of the skin; the purpose that the photosensitizer for photodynamic therapy needs to be subjected to intravenous injection to achieve selective injury can be changed, the light shielding time of photodynamic therapy is shortened, the liver and kidney toxicity of a patient is reduced, and precise regional drug delivery and treatment of photodynamic therapy are achieved.

Description

technical field [0001] The present invention designs a dissolvable microneedle and a drug feeding device. By mixing photosensitizers and soluble components to form a solid microneedle array that can be dissolved in the skin after piercing the skin, the microneedle can be injected to a specific depth of the skin. Changing photosensitizers for photodynamic therapy requires intravenous injection to achieve selective damage. Background technique [0002] At present, there are still a large number of patients with skin diseases in my country who are in urgent need of treatment, such as vitiligo, melanoma, skin cancer, and port wine stains, etc., and smearing and intravenous injection are the most common methods of photodynamic therapy for skin diseases. In particular, there are side effects such as the first-pass effect of the liver, poor controllability of blood drug concentration, and the need for a long time to avoid light for residual photosensitizers in the photodynamic skin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00A61N5/06
CPCA61M37/0015A61N5/062
Inventor 胡晓明王旭赵慧婷魏泽文
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
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