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Method for determining fingerprint spectrum and index component content of high-quality atractylodes macrocephala koidz medicinal material

A technology of fingerprinting and high-quality medicinal materials, which is applied in material separation, measuring devices, and analysis of materials, etc., can solve the problems of excessive loss of reagents, unstable monomers, and long time consumption, and achieve the effect of improving quality control standards

Pending Publication Date: 2022-03-18
上海海虹实业(集团)巢湖今辰药业有限公司
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AI Technical Summary

Problems solved by technology

At present, the qualitative analysis of Atractylodes macrocephala is mainly fingerprint analysis, but the method established before takes a long time, consumes more reagents, is not conducive to high-throughput analysis, and is not sufficient for the identification of complex components; Quantitative analysis of ingredients, there is no unified standard at present, it is difficult to accurately and comprehensively reflect the intrinsic quality of Chinese herbal medicines
The multi-indicator quality control and evaluation mode of traditional Chinese medicine requires reference substances with various components, but some traditional Chinese medicine reference substances are difficult to separate, unstable monomers, difficult to supply or high supply prices, which make them unable to meet the requirements of traditional Chinese medicine quality control and new drug development. Due to the needs of research and development, the number of compounds whose content has been determined in Atractylodes macrocephala is relatively small
Therefore, aiming at the defects of insufficient identification of the above-mentioned complex components and few quantitative chemical components, the present invention provides a method for determining the fingerprints of Atractylodes macrocephala and the content of index components. analyze

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  • Method for determining fingerprint spectrum and index component content of high-quality atractylodes macrocephala koidz medicinal material
  • Method for determining fingerprint spectrum and index component content of high-quality atractylodes macrocephala koidz medicinal material
  • Method for determining fingerprint spectrum and index component content of high-quality atractylodes macrocephala koidz medicinal material

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Embodiment Construction

[0028] The following examples are used to illustrate the method, but are not intended to limit the scope of the invention.

[0029] In order to better understand the contents of the present invention, the present invention will be further described below in conjunction with the accompanying drawings and specific embodiments.

[0030] Step 1: Using high performance liquid chromatography full-wavelength visible ultraviolet detection method to establish the fingerprint of the high-quality medicinal material of Atractylodes macrocephala

[0031] 1. Test materials, instruments and reagents

[0032] Test materials: The samples of Atractylodes macrocephala used were 8 batches of whole roots of Atractylodes macrocephala collected from different producing areas in Anhui Province, crushed, passed through No. 4 sieve of Pharmacopoeia, and set aside. The details of the test materials are listed in Table 1.

[0033] Table 1 Atractylodes sample information table

[0034]

[0035] Inst...

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Abstract

The invention relates to a method for determining the fingerprint spectrum of a high-quality medicinal material of bighead atractylodes rhizome and the content of index components, which comprises the following steps of: 1, establishing the fingerprint spectrum of the high-quality medicinal material of bighead atractylodes rhizome by adopting a high-performance liquid-phase full-wavelength visible ultraviolet detection method; 2, identifying chromatographic peaks of the fingerprint spectrum in the step 1 by using a liquid chromatography-mass spectrometry technology, and determining common fingerprint peaks and non-common peaks of ultraviolet detection; and step 3, carrying out content determination on two index components which are clear in structure and easy to detect by adopting a high performance liquid evaporative light scattering detection method.

Description

technical field [0001] The invention belongs to the field of analysis of traditional Chinese medicines and content determination of Chinese medicinal materials, and in particular relates to a method for determining the fingerprints of high-quality medicinal materials of Atractylodes macrocephala and the content of index components. Background technique [0002] Atractylodes macrocephala (Atractylodes macrocephala Koidz.), a traditional Chinese medicine, is the dried rhizome of Atractylodes macrocephala Koidz. It is cultivated in most areas of my country, such as Anhui, Zhejiang, Jiangxi, Hunan, and Sichuan. Clinically, it is mainly used to invigorate the spleen, warm in nature, sweet in taste, slightly pungent with bitterness, and has the functions of invigorating the spleen and replenishing qi, drying dampness and diuresis, antiperspirant and antifertility. , spontaneous sweating, restless fetal movement embolism. [0003] The efficacy of Chinese medicinal materials is clo...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/86G01N30/02G01N30/74G01N30/34G01N30/72G01N30/06G01N30/14G01N30/88
CPCG01N30/8686G01N30/02G01N30/74G01N30/34G01N30/72G01N30/06G01N30/14G01N30/8634G01N30/8679G01N30/88G01N2030/146G01N2030/884
Inventor 余之宝彭国平张先文金玉柳思洋张先顺
Owner 上海海虹实业(集团)巢湖今辰药业有限公司
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