Soluble microneedle photodynamic therapy device

Abstract

The invention relates to an integrated photodynamic therapy device using soluble microneedles, which is formed by arrayed microneedles and a light source, so that a photodynamic therapeutic agent can accurately enter the skin in the microneedles and can be quickly released, and photodynamic therapy can be carried out in time; according to the integrated treatment device, the situation that a photosensitizer for photodynamic therapy needs to be subjected to intravenous injection to achieve the purpose of selective injury is changed, the light shielding time of photodynamic therapy is shortened, the flexible substrate array can be designed into various shapes according to the skin lesion shape of a patient, and precise area treatment of photodynamic therapy is achieved.

Description

technical field [0001] The invention relates to a soluble microneedle photodynamic therapy device, which forms a microneedle array that can dissolve in the skin after piercing the skin by mixing a photosensitizer with a soluble component or containing it in a shell of the soluble component. The soluble microneedle array It is connected as a whole with a flexible lighting source, which can realize on-demand treatment of skin lesions. Background technique [0002] At present, there are still a large number of patients with skin diseases in my country who are in urgent need of treatment, such as vitiligo, melanoma, skin cancer, and port wine stains, etc., and smearing and intravenous injection are the most common methods of photodynamic therapy for skin diseases. In particular, there are side effects such as the first-pass effect of the liver, poor controllability of blood drug concentration, and the need for a long time to avoid light for residual photosensitizers in the photo...

AI Technical Summary

Problems solved by technology

In particular, there are side effects such as the first-pass effect of the liver, poor controllability of blood drug concentration, and the need for a long time to avoid light for residual photosensitizers in the photodynamic skin disease treatment methods using photosensitizers.

At the same time, the current micro-needle treatment is more practical to smear the drug on the skin surface, and the micro-needle made of stainless steel and other materials is used to pierce the skin to achieve drug delivery. Because the tip of the metal micro-needle is thin, it is easy to cause the tip to break after repeated use, forming a therapeutic effect. Hidden danger

For some applications, soluble microneedles have been developed, which gradually dissolve and diffuse in the skin to release drugs, and deliver the drugs through the skin to the dermis or the blood circulation system, but most of the microneedles that are not specially used for photosensitizers are designed to increase the slowing time. It is hoped that the drug contained in the microneedle can increase the sustained release time in the skin, which is not suitable for the demand of photodynamic therapy to decompose as soon as possible after light exposure.

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