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A kind of soluble microneedle and medicine feeding device

A soluble and microneedle technology, which is applied in the direction of microneedles, needles, and medical devices, can solve the problems of inapplicable rapid decomposition and increase the sustained release time, so as to reduce liver organ damage and economic burden, reduce scars, Effect of reducing absorption loss

Active Publication Date: 2022-08-05
BEIJING INSTITUTE OF TECHNOLOGYGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current soluble microneedles that are not specially used for photosensitizers are mostly designed to increase the sustained release time. It is hoped that the drug contained in the microneedles can increase the sustained release time in the skin, which is not suitable for photodynamic therapy. Decomposition requirements

Method used

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  • A kind of soluble microneedle and medicine feeding device
  • A kind of soluble microneedle and medicine feeding device
  • A kind of soluble microneedle and medicine feeding device

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Embodiment Construction

[0022] The present invention will be described in further detail below in conjunction with the accompanying drawings and examples. Here, the exemplary embodiments of the present invention and their descriptions are used to explain the present invention, but not to limit the present invention.

[0023] A soluble solid microneedle and a medicine feeding device for photodynamic therapy of the present invention, specifically:

[0024] Solid microneedles are composed of soluble biological tissue materials (such as sodium hyaluronate, polylactic acid), and add a certain concentration of photodynamic therapy drug preparations (such as 1% concentration of photosensitizer Hemporfin, ALA5) according to the therapeutic dose. Molded, vacuumed, and dried to form a hard, soluble solid. like figure 1 and 2 As shown, the microneedle mainly includes two parts: a tip part 102 and a base part 101, the middle of the tip part and the base part can be regarded as a transition part, wherein the d...

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Abstract

The present invention designs a soluble solid micro-needle for photodynamic therapy and a drug-injecting therapy device. The photodynamic therapy agent is mixed with the inherent components of the human body (glucuronic acid, polylactic acid) in a certain proportion to form a skin-piercing device. The microneedle array can be injected into a specific depth of the skin, and the photosensitizers that can change the photodynamic therapy need to be injected intravenously to achieve the purpose of selective damage, and reduce the photodynamic therapy light-avoidance time and the patient's liver and kidney toxicity. Precise regional drug delivery and treatment for photodynamic therapy.

Description

technical field [0001] The present invention designs a soluble microneedle and a medicine feeding device. By mixing a photosensitizer and a soluble ingredient to form a solid microneedle array that can be dissolved in the skin after piercing the skin, the microneedle can be injected into a specific depth of the skin, and the Alteration of photodynamic therapy photosensitizers requires the use of intravenous injections to achieve selective injury. Background technique [0002] At present, there are still a large number of patients with skin diseases in our country who are in urgent need of treatment, such as vitiligo, melanoma, skin cancer and port-wine stains, etc. The administration methods such as smearing and intravenous injection are the most common methods of photodynamic therapy for skin diseases. In particular, photodynamic dermatological treatment methods using photosensitizers all have side effects such as first-pass effect of the liver, poor controllability of bloo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M37/00A61N5/06
CPCA61M37/0015A61N5/062
Inventor 胡晓明王旭赵慧婷魏泽文
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
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