PH response type hydrogel for oral periodontal tissue treatment

Abstract

The invention relates to the technical field of oral treatment, in particular to PH response type hydrogel for oral periodontal tissue treatment, and a preparation method of the PH response type hydrogel comprises the following steps: preparing ZIF-8 nanoparticles, synthesizing a ZIF-8-EGCG drug loading system, detecting the drug release characteristic of the drug loading system under an acidic condition, and applying the successfully synthesized nanoparticles to subsequent experiments. According to the invention, EGCG is used as a medicine, ZIF-8 nanoparticles which are prepared in the earlier stage and have an osteogenesis promoting effect are used as a carrier, a ZIF-8-EGCG nano medicine carrying system is synthesized, and hydrogel which can be originally injected is used, so that wound caused by periodontal surgery can be reduced to the greatest extent, and the comfort level of a patient is improved; secondly, the hydrogel in a fluid state can finally form amorphous hydrogel along with an injection position, so that body injury caused by an irregular shape is avoided, and the problems that a traditional Chinese medicine is relatively poor in chemical stability, easy to oxidize, low in bioavailability and the like, and the problem that a patient feels uncomfortable due to large operative trauma are solved.

Description

technical field [0001] The invention relates to the technical field of oral cavity treatment, in particular to a pH-responsive hydrogel for oral cavity periodontal tissue treatment. Background technique [0002] Periodontitis is a chronic infectious disease of periodontal tissue, which is characterized by periodontal tissue destruction, periodontal pocket formation, and alveolar bone resorption, which will eventually lead to gradual destruction of periodontal ligament and alveolar bone, and loss of periodontal attachment. This will lead to tooth loss and loss of chewing function. Establishing a good local immune environment through early regulation of inflammatory response will be conducive to the regeneration of bone tissue, and if the inflammatory response persists, it will directly affect the repair effect of bone defects. Therefore, effective control of inflammation and Promoting the regeneration of periodontal support tissue is still an important direction of clinical r...

AI Technical Summary

Problems solved by technology

[0003] Epigallocatechin gallate (EGCG) is a natural phenolic active substance extracted from tea leaves, which has anti-oxidant and anti-inflammatory properties, inhibits alveolar bone resorption, inhibits bacterial adhesion and biofilm formation, and protects epithelial integrity and other aspects have important effects, but EGCG, like other antioxidant drugs, has disadvantages such as poor chemical stability, easy oxidation, and low bioavailability, which limits its further application. EGCG loaded on the carrier may be a One of the effective methods to solve the existing problems at present, ZIF-8 nanocarrier has a large pore size and high specific surface area, which provides the possibility for efficient drug delivery, and ZIF-8 itself has the characteristics of promoting osteogenic differentiation, so this study EGCG and ZIF-8 are proposed to construct a drug-loading system, in which a stable Zn-polyphenolic compound is formed in coordination, and then combined with in situ injectable hydrogel to construct a nanocomposite hydrogel loaded with EGCG for controlled release system

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