Multi-cancer screening serum biomarker group and application thereof

A biomarker and screening technology, applied in the field of biomedicine, to achieve the effects of less invasiveness, high detection sensitivity and specificity, and low sample consumption

Pending Publication Date: 2022-04-19
FUDAN UNIV
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen that if a variety of cancer detection technologies are really used for population screening, detection sensitivity and specificity are the biggest challenges

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Multi-cancer screening serum biomarker group and application thereof
  • Multi-cancer screening serum biomarker group and application thereof
  • Multi-cancer screening serum biomarker group and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] This embodiment provides a group of serum biomarkers for multi-cancer screening, selected from the following combinations of all 192 proteins:

[0042] PZP, ITIH4, ALAD, F7, C1R, BST1, SERPINF1, IGLV3-21, FCN3, F2, APOA2, HP, CRTAC1, FCGR3A, MST1, IGLV7-43, ITIH1, F10, LCAT, CFHR3, SHBG, PTGDS, SAA4, JCHAIN, FN1, CFHR1, SERPINA1, APOC1, CFH, FBLN1, PON1, SPP2, IGHA1, IGKV4-1, ECM1, IGLV3-19, CPN2, MCAM, AGT, A2M, AFM, C3, PI16, PPBP, APCS, IGFALS, GPX3, HBB, SELENOP, IGHV1-2, TGFBI, F5, NID1, SERPIND1, HRG, IGHV1-46, IGKV1D-16, MASP2, CST3, IGHV4-34, SERPINA3, IGKV2-30, VWF, MPO, QSOX1, AZGP1, FGB, PGLYRP2, C8A, APOF, ORM2, SERPING1, HSPA5, CFD, LRG1, IGKV3-11, COMP, IGFBP2, C8G, AMBP, C9, APOH, APOA4, APOO, CDH13, LUM, IGHV3-7, APOC2, FGG, A1BG, FETUB, TTR, CP, LYZ, APOC3, CFI, GSN, ACTA1, VASN, PTPRF, SAA1, IGHG4, C1RL, LBP, APOL1, CLU, HPX, F9, C6, IGKV1-39, C4BPA, C8B, ORM1, SERPINA7, C1QB, AHSG, C5, CFB, IGKV1-16, IGHM, C1QC, APOE, PROS1, IGKV3-15, APOM, APOB, C1...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
collision energyaaaaaaaaaa
Sensitivityaaaaaaaaaa
Login to view more

Abstract

The invention relates to a multi-cancer screening serum biomarker group and application thereof. 192 kinds of cancer secreted serum proteins are defined through targeted proteomics and are used for detection and positioning of liver cancer, gastric cancer, lung cancer and breast cancer. Compared with an existing multi-cancer screening method based on circulating tumor DNA (ctDNA) and known tumor markers, the multi-cancer screening method has the advantages that a multi-cancer screening model is established by applying a proteomics technology based on targeted mass spectrometry and a machine learning method, higher detection sensitivity and specificity are shown, the sample consumption is extremely low (1 microliter serum), the invasiveness of blood detection is smaller, and the detection time is shortened. And the device is more attractive clinically and meets the requirements of precise medicine.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a group of serum biomarkers for multi-cancer screening and applications thereof. Background technique [0002] Cancer is the second leading cause of death worldwide, and its morbidity and mortality continue to increase. In particular, liver cancer (HCC), gastric cancer (GC), lung cancer (LC), and breast cancer (BC) are four cancers with high morbidity and mortality worldwide. Early detection and early treatment are the most effective ways to improve the treatment effect and survival rate of cancer patients. However, screening modalities and preparations vary for a single cancer, which reduces the integration and efficiency of screening programs, harms patient compliance, and increases overall economic costs. [0003] The new technology of simultaneous detection of multiple cancers can realize the simultaneous detection and classification of multiple cancers by d...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574G01N33/68G06K9/62G06N20/00G16B5/00G16B35/20G16B40/00
CPCG01N33/574G01N33/6848G16B5/00G16B35/20G16B40/00G06N20/00G01N2570/00G06F18/24323
Inventor 申华莉胡安琪张磊
Owner FUDAN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap