Application of composition in preparation of medicine for treating or preventing depression

A composition and depression technology, applied in the direction of drug combination, pharmaceutical formula, anhydride/acid/halide active ingredient, etc.

Active Publication Date: 2022-05-13
TIANJIN ZHONGXIN PHARMA GRP CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention studies the properties of ferulic acid and ligustilide individually and in combination, and finds that the two have a vasodilation effect respectively, and the combination of the two has a synergistic effect, which has not been reported in the existing literature

Method used

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  • Application of composition in preparation of medicine for treating or preventing depression
  • Application of composition in preparation of medicine for treating or preventing depression
  • Application of composition in preparation of medicine for treating or preventing depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0142] The composition contains ferulic acid and Z-ligustilide, and the weight ratio of the two is:

[0143] Ferulic acid: Z-ligustilide = 1:4.

[0144] The composition is obtained by mixing ferulic acid and Z-ligustilide, or by mixing the extract of traditional Chinese medicine containing ferulic acid and the extract of traditional Chinese medicine containing Z-ligustilide, or by co-extracting Angelica sinensis and Rhizoma Chuanxiong get.

Embodiment 2

[0146] The composition contains ferulic acid and Z-ligustilide, and the weight ratio of the two is:

[0147] Ferulic acid: Z-ligustilide = 1:5

[0148] The composition is obtained by mixing ferulic acid and Z-ligustilide, or by mixing the extract of traditional Chinese medicine containing ferulic acid and the extract of traditional Chinese medicine containing Z-ligustilide, or by co-extracting Angelica sinensis and Rhizoma Chuanxiong get.

Embodiment 3

[0150] The composition contains ferulic acid and Z-ligustilide, and the weight ratio of the two is:

[0151] Ferulic acid: Z-ligustilide = 1:6

[0152] The composition is obtained by mixing ferulic acid and Z-ligustilide, or by mixing the extract of traditional Chinese medicine containing ferulic acid and the extract of traditional Chinese medicine containing Z-ligustilide, or by co-extracting Angelica sinensis and Rhizoma Chuanxiong get.

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Abstract

The invention relates to application of a pharmaceutical composition. The application comprises treatment or prevention of depression. The composition contains ferulic acid and ligustilide, the weight ratio of ferulic acid to Z-ligustilide is 1: (4-10), or ferulic acid to Z-ligustilide is 1: 4, or ferulic acid to Z-ligustilide is 1: 10, or ferulic acid to Z-ligustilide is 1: 9.43, and the composition can also contain senkyunolide I, (-)-apigenyl lactide and senkyunolide H, all the components are as follows in percentage by weight;

Description

technical field [0001] The present invention relates to a kind of composition and its pharmaceutical preparation, especially a kind of drop pill preparation, described preparation has the effect of treating headache, dizziness, apoplexy, blurred vision, forgetfulness, insomnia, especially has the effect of treating or preventing depression Effect. Background technique [0002] It is known that many traditional Chinese medicines have the effects of regulating qi and activating blood circulation, removing blood stasis and relieving pain. As the disclosed dropping pill of State Food and Drug Administration National Drug Standard YBZ00432005-2009Z. [0003] Chinese patent 97105810.5 discloses a dripping pill containing Rhizoma Chuanxiong and Angelica ether extracts and a preparation method thereof. The preparation process disclosed in its embodiment is as follows: take 50% each of Rhizoma Chuanxiong and Angelica coarse powder, mix evenly, use 95% ethanol as solvent, completely...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61P25/24A61K31/192A61K31/201A61K31/20
CPCA61K31/365A61K31/192A61P25/24A61K31/201A61K31/20A61K2300/00
Inventor 周鸿刘丹刘彤王金磊
Owner TIANJIN ZHONGXIN PHARMA GRP CO LTD
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