The invention discloses meal replacement powder capable of expelling toxins and nourishing faces. The meal replacement powder is prepared from the following raw materials in parts by weight of 2-5 parts of wheat kernels, 2-5 parts of brown rice, 2-5 parts of millet, 2-5 parts of coix seeds, 2-5 parts of red jujubes, 2-5 parts of rice beans, 1.5-4 parts of Chinese wolfberry fruits, 1.5-3 parts of black beans, 1.5-3 parts of soybeans, and 1.5-3 parts of sorghum rice. A preparation method of the meal replacement powder comprises the following steps of thoroughly cleaning the raw materials, performing draining, and removing cores from red jujubes; and performing low-temperature baking on the raw materials, performing grinding to obtain powder, performing screening with an 80-100-mesh sieve, performing mixing in proportion, and performing packing to obtain bags each of which weighs 20g. The meal replacement powder is made by mixing powder prepared by processing the wheat kernels, the brownrice, the millet, the coix seeds, the red jujubes, the rice beans, the Chinese wolfberry fruits, the black beans, the soybeans and the sorghum rice, and the prepared meal replacement powder is rich incellulose, amino acids, protein, minerals and the like, rich in nutrients, good in mouth feel, simple in eating method, safe, reliable, free from toxic and side effects, low in calorie, and high in satiety, has the efficacy of regulating vital energy, promoting blood circulation, expelling toxins and nourishing faces, and can be eaten for a long term.