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Medical nano-carbon tube composition, preparation method and its application

A technology of carbon nanotubes and compositions, which is applied in the field of pharmaceutical carbon nanotube compositions and its preparation, and can solve problems such as the decomposition of guiding agents

Inactive Publication Date: 2007-08-15
杨维稼 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, no excellent oral-directed drug has been released, because the directing agent (antibody) will inevitably be decomposed during its absorption process after oral administration.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0106] The preparation method of refining commercially available carbon nanotubes into medicinal carbon nanotubes:

[0107] 10g of commercially available carbon nanotubes, add 100mL of 0.5N hydrochloric acid, soak, shake, treat for 8 hours, centrifuge to separate the residue, wash with water to pH 5-6, add 100mL of 0.5N sodium hydroxide, soak, shake, treat 8 After 1 hour, the residue was separated by centrifugation, washed with water to pH 8~9, added 100 mL of 0.5N hydrochloric acid, soaked, shaken, treated for 8 hours, centrifuged to separate the residue, washed with water to near neutral pH, centrifuged to take the residue, dried at 100°C, 400°C Activated for 3 hours and allowed to cool to obtain medicinal carbon nanotubes A that meet the requirements.

[0108] The specific surface area of ​​the medicinal carbon nanotube A is 820M after testing 2 / g, ash content is lower than 2%, loss on drying is lower than 2%, lead, cadmium, arsenic, mercury content are lower than 1ppm re...

Embodiment 2

[0111] Get the medicinal carbon nanotubes A50g prepared in Example 1, add it to a 95% alcohol solution containing 10% propolis, and ultrasonically vibrate for 4 hours to fully remove the air in the medicinal carbon nanotubes, so that propolis can enter the interior of the carbon tubes. , remove the alcohol, and obtain the dry product B of carbon nanotubes.

[0112]Take 0.1g of dry product B, add it to 100ml of a solution containing 0.5% Tween-80 and 10% PVP by weight, shake well, and use an ultrasonic instrument with power > 100W to treat it for 200 minutes, so that the medicinal carbon nanotube particles are fully dispersed , to obtain a uniform and fully dispersed suspension, filter it, take the filtrate, pack it into a suspension of 100 mg / bottle, seal it, and sterilize it under high pressure at 120° C. to obtain propolis injection composition C.

Embodiment 3

[0114] Get 50 g of medicinal carbon nanotubes B prepared in Example 2, add 50 g of pine pollen, 50 g of broken ganoderma lucidum spore powder, mix the three, pulverize through an 80-mesh sieve, add 0.1 g of magnesium stearate, and pack 50 capsules , made of carbon nanotube composition D oral capsule.

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Abstract

A medical carbon nanotube composition for preparing the medicines to treat cancer, cardiovascular and cerebrovascular diseases and rheumatic and rheumatoid diseases is prepared from medical carbon nanotubes, active medicinal components and leading agent. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a medicinal carbon nanotube composition and a preparation method thereof. The present invention also relates to the medicinal carbon nanotube composition used in the preparation of medicines for the treatment of cancer, medicines for the treatment of cardiovascular and cerebrovascular diseases, as well as for the treatment of rheumatism and rheumatoid diseases application in medicine. Background technique [0002] From the end of the 20th century to the 21st century, human diseases are facing major changes. The main killers have evolved from infectious diseases to tumors and cardiovascular and cerebrovascular diseases. In addition, autoimmune diseases formed due to immune disorders have been increasingly recognized and found to be a serious problem. Taking tumors as an example, 7 million people die from malignant tumors in the world every year, and about 2 million new cases occur in China every year. Cancer has become one of t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/44A61K47/04A61K45/06A61K9/02A61K9/06A61K9/08A61K9/12A61K38/43A61K35/64A61P9/10A61P29/00A61K35/644
Inventor 杨维稼孙汉翔孙逸萍
Owner 杨维稼
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