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Gypsum composition for department of orthopedics

A composition and gypsum technology, applied in bone implants, medical science, prostheses, etc., can solve the problems of time urgency, inability to guarantee complete injection, narrow semi-consolidation time range, etc., and achieve the effect of promoting growth

Inactive Publication Date: 2003-11-26
CENT MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Traditional orthopedic gypsum compositions have a relatively narrow range of semi-consolidation time and operating time, for example, the semi-consolidation time is about 2.5 to 3 minutes, and the operating time is about 3.5 to 4 minutes, that is, orthopedic gypsum and aqueous solution Within 2.5 minutes after mixing, inject it into body fluid, the orthopedic plaster composition will disperse; inject within 2.5 to 3 minutes after mixing, there is no guarantee that it will not disperse; inject within 3.5 to 4 minutes after mixing, although it will not disperse , but it cannot be guaranteed to be fully injected; after 4 minutes of mixing, the orthopedic plaster composition cannot be injected into the human body, that is, only after 3 to 3.5 minutes of mixing, can the orthopedic gypsum composition achieve the best effect
Low acceptance by the medical community due to short time frame suitable for infusion and time urgency

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～6

[0020] Stir with 12g hemihydrate gypsum and the water of the volume listed in Table 1 for 30 seconds, then add the plasma of the volume listed in Table 1, and stir evenly for 2 minutes, then, measure its operation time in normal saline, and it is substantially completely hardened The results of the consolidation time and semi-consolidation time are shown in Table 1.

[0021] Table 1

Embodiment 7～8

[0025] Similar to Example 4, but 0.5 ml of plasma (Example 4) was replaced with 0.5 ml of whole blood (Example 7) and 0.5 ml of serum (Example 8) respectively. The results are shown in Table 2.

[0026] Table 2 Example operating time Consolidation time semi-consolidation time 7 <14 points 32-35 points 6 points 8 <25 points 110-120 points 10 points

Embodiment 9～12

[0028] Mix the ingredients listed in Table 3 evenly into an aqueous solution, then mix with 10 grams of hemihydrate gypsum, stir for 2.5 minutes, and then measure its operation time in saline, the solidification time of substantially complete hardening and the semi-consolidation time. Item time records, the results are shown in Table 3.

[0029] table 3

[0030] Example water *1 plasma MC *2 glycerin Operation Consolidated Semi-consolidated

[0031] time time time 9 1.8 0.2 0.5 0.2 7 minutes 25-28 minutes 4 minutes 10 1.6 0.4 0.5 0.2 16 minutes 25-28 minutes 5 minutes 11 1.4 0.6 0.5 0.2 17 minutes 30-32 minutes 5 minutes 12 1.0 1.0 0.5 0.2 25 minutes 60-65 minutes 8 points

[0032] *1 Water, plasma, MC, glycerol, etc. are all measured in volume (ml).

[0033] *2 MC is the abbreviation of methyl cellulose (Methyl Cellulose).

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Abstract

The gypsum composition for orthopedic injection is prepared through mixing gypsum with water solution in the weight ratio of 2-5 through stirring to form semi-concreted matter. The water solution contains serum, plasma or whole blood in 2-40 vol% essentially.

Description

technical field [0001] The invention relates to a method for controlling the operating time of a gypsum composition for orthopedics and the gypsum composition for orthopedics. Background technique [0002] Using gypsum as a bone substitute is a known technology in the medical field, but using gypsum as an injected bone substitute is an emerging technology, such as the applicant's patent No. 6251139 obtained in the United States. The main difficulty of this emerging technology is that the working time and semi-solidification time of orthopedic plaster are not easy to control. The so-called operating time here refers to the time required from the time when the orthopedic gypsum is mixed with the aqueous solution until it is impossible (or extremely difficult) to extrude the mixed orthopedic gypsum composition from the syringe; and the so-called semi-consolidation time, It refers to the time required from the time when the orthopedic gypsum is mixed with...

Claims

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Application Information

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IPC IPC(8): A61F2/28A61L27/00A61L27/02
Inventor 林圣富林智一潘宏维吴少文薛文景
Owner CENT MEDICAL TECH
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