Anti-hsv agent for inhibiting replication of HSV-1 and HSV-2 and method of producing a substance having anti-HSV activity

A technology of -HSV, active ingredients, applied in the field of anti-HSV drugs, can solve the problem of epithelial replication not establishing latent infection and so on

Inactive Publication Date: 2005-04-06
田中昭子 +2
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, other studies have confirmed that epithelial replication is not a prerequisite for the establishment of latent infection in animal models

Method used

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  • Anti-hsv agent for inhibiting replication of HSV-1 and HSV-2 and method of producing a substance having anti-HSV activity
  • Anti-hsv agent for inhibiting replication of HSV-1 and HSV-2 and method of producing a substance having anti-HSV activity
  • Anti-hsv agent for inhibiting replication of HSV-1 and HSV-2 and method of producing a substance having anti-HSV activity

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Embodiment Construction

[0032] Plants have been a major source of medicinal compounds for thousands of years. Currently, chemical constituents and analogs derived from plant materials account for a major part of clinically used drugs. One such plant product is derived from the cones of various pine trees. Any commercially available pine cone raw material can be used to prepare anti-HSV substances. The substance, having a defined degree of activity, can be extracted from pine cones using an aqueous KOH base solution. The substances contained in the extract and used as active ingredients are high molecular weight substances. The most potent substances are named PCC or PCE.

[0033] The extraction solution should be concentrated to the desired concentration, neutralized, if necessary, with an appropriate acid, and then freeze-dried to form a solution or solid of the appropriate concentration. The product was used as active ingredient without further fractional purification. Refrigerate material not...

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Abstract

An anti-HSV agent that inhibits the replication of HSV-1 and HSV-2 that is derived from a plant. Further, provided is a method of producing a potassium hydroxide extract of pine cone having anti-HSV activity, and the anti-HSV agent.

Description

field of invention [0001] The present invention relates to an anti-HSV medicine, which is derived from plants and can inhibit the replication of HSV-1 and HSV-2, and also relates to a method for producing plant-derived substances with anti-HSV activity. Background of the invention [0002] Herpes simplex virus, including herpes simplex virus type I and type II (HSV) infections, afflicts approximately 50 million Americans, with approximately 500,000 new cases occurring each year. About 30 million Americans are infected with genital herpes virus (American Public Health Institute). The HSV virion is a large (100 to 150 mμg), enveloped virus with an icosahedral capsid. It contains double-stranded DNA and its genome encodes at least 70 polypeptides. This large amount of regulatory information allows virus particles to control their gene expression and adapt to a variety of complex situations in infected cells. Herpes simplex virus enters the host through direct contact and spr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/00A61KA61K36/15A61P31/22
CPCA61K36/15A61P31/22
Inventor 田中昭子约翰·杰西普艾米·西尔斯
Owner 田中昭子
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