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Lornoxicam dropping pill and its preparing method

A technology of lornoxicam and dropping pills is applied in the field of medicines in which thiazide derivative lornoxicam is an active ingredient, and can solve the problems such as no reports, and achieve the advantages of increasing dissolution rate, taking safety and high bioavailability. Effect

Inactive Publication Date: 2005-12-21
贵阳高新瑞得科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no lornoxicam dripping pills on the market, and there is no relevant report

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0026] Embodiment Take lornoxicam 500g, add heating and melting, the temperature is 80 ℃ by accounting for 40% polyethylene glycol 4000 of total amount and 9500g of auxiliary materials that account for total amount 60% polyethylene glycol 6000 and mix; About 10kg of the molten mixture is transferred to the dropping pill machine and dripped at a temperature of 75°C; the liquid medicine is dropped into a liquid paraffin coolant and cooled at a temperature of 10°C; the coolant is dried with a suction cloth, and the pills are selected to obtain Eucalyptus menthol Oil drop pills; then packaged for delivery.

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PUM

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Abstract

The present invention discloses chlortenozicam dripping pills and preparation method. Said dripping pill preparation belongs to a medicine for resisting inflammation and stopping pain, and is formed from 1.5%-20% of medicine and 80-99.5% of auxiliary material, in which the medicine is chlortenozicam and the auxiliary material is polyethylene glycol. Besides, said invention also provides the concrete steps of its preparation method, and said chlortenozicam dripping pills can be used for curing various acute pains, arthralgia, inflammation pain, acute lumber vertebrae pain and sciatica, etc.

Description

technical field [0001] The invention belongs to anti-inflammatory and analgesic medicines, in particular to medicines with thiazide derivative lornoxicam as active ingredients, and also relates to a preparation method thereof. Background technique [0002] Lornoxicam belongs to the non-steroidal anti-inflammatory analgesics, which is a thiazide derivative, and it has strong analgesic and anti-inflammatory effects. Its mechanism of action is as follows: one is to inhibit the synthesis of prostaglandins by inhibiting the activity of cyclooxygenase (COX), but it does not inhibit the activity of 5-lipid oxidase, so it does not inhibit the synthesis of leukotrienes; the other is to activate opioids Neuropeptide system exerts central analgesic effect. The advantage of Lornoxicam is that it has a significant analgesic effect, especially for postoperative analgesia, the curative effect is equal to morphine and pethidine, better than tramadol, and its adverse...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/542
Inventor 李向东卢顺林
Owner 贵阳高新瑞得科技开发有限公司
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