Method for inspecting infectious gene MBL related to SARS CoV infection and MBL infectious gene

A genotype and gene technology, applied in the field of individual susceptibility and its genetics detection, can solve the problems of differences in susceptibility to SARS-CoV infection, affecting the expression level of MBL, etc.
CN1896272AInactive Publication Date: 2007-01-17INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
Publication Date
2007-01-17
Estimated Expiration
Not applicable · inactive patent
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Abstract

The present invention relates to the PCR product sequencing assay of mannose-binding lectin gene (MBL) correlative with the susceptibility of SARS-CoV infection. The present invention also relates to the assay of the haplotypes correlative with the susceptibility of SARS-CoV infection that is composed of three single nucleotide polymorphism sites(SNPs): MBL gene G-550C,G-221C and G+230A. The said assay is to determine the genotype of the three SNPs by sequencing the PCR product first and then to calculate the haplotypes with PHASE programme. The present invention further relates to the detection kit of the above SNPs and the usage. Furthermore, the present invention combines the G+230A polymorphism sites and the haplotype composed of G-550C,G-221C and G+230 with SARS-CoV susceptibility, confirms that MBL is a new susceptibility gene included in SARS-CoV infection, and provides new genetic counseling content for the prevention and control of SARS-CoV infection of the population.
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Description

technical field

[0001] The invention relates to the individual susceptibility and genetic detection method in the prevention of severe acute respiratory syndrome (Severe Acute Respiratory Syndrome, SARS) population. Specifically, the present invention relates to a genotype detection method of the susceptibility gene mannose-binding lectin (mannose-binding lectin, MBL) gene associated with SARS coronavirus (SARS Coronavirus, SARS-CoV) infection. The present invention further relates to a detection kit for the above-mentioned susceptibility gene genotype, and the application of the kit. In addition, the present invention also relates to the application of the above detection method and susceptibility gene in the prevention and control of SARS and genetic counseling. Background technique

[0002] SARS is a newly identified human infectious disease caused by a novel coronavirus, SARS-CoV. As of the end of June 2003, more than 8,000 SARS cases were reported in more than 25 coun...

Claims

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