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Application of Resistin binding polypeptide for preparing medicine promoting insulin secretion

A technology of resistin and peptide binding, applied in the field of genetic engineering, can solve the problems of unreported function and impaired function of pancreatic islet B cells

Inactive Publication Date: 2007-02-07
郭锡熔 +8
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

2. Impaired islet B cell function
[0008] However, the functions of these Resistin-binding polypeptides are not reported in the prior art

Method used

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  • Application of Resistin binding polypeptide for preparing medicine promoting insulin secretion
  • Application of Resistin binding polypeptide for preparing medicine promoting insulin secretion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] 1. Obtaining the peptide sequence

[0020] The cDNA sequences of three Resistin-binding polypeptides were screened by phage surface hybridization technology, and translated into the following amino acid sequences according to the translation code:

[0021] 1. AWILLQGYPGSSS (SEQ ID No. 1);

[0022] 2. AWILFRAASDIAIPS (SEQ ID No. 2);

[0023] 3. AWILYLSFAFCIYSLITCLGVICQAWTLMHLHKFYHCSELKATE (SEQ ID No. 3);

[0024] They all contain a consensus sequence (AWIL).

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PUM

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Abstract

The invention relates to an application of Resistin bind polypeptide to prepare the drug that accelerates insulin secretion, wherein the invention provides a relative application method, to clear the function of polypeptide.

Description

technical field [0001] The invention belongs to the field of genetic engineering and relates to the application of Resistin-binding polypeptides in the preparation of drugs for promoting the secretion of pancreatic islet cells. Background technique [0002] Type 2 diabetes is a disease that seriously affects human health and quality of life. It not only affects 6% of adults in western countries, but its incidence tends to be younger, and it is growing rapidly at an annual growth rate of 6%. Its harmfulness and rising morbidity among children have attracted extensive attention of scholars from various countries, and has become an important research direction in the field of medical research. [0003] It is known that there are two basic changes in type 2 diabetes: 1. Insulin resistance. 2. The function of islet B cells is impaired. Obesity is an important risk factor for type 2 diabetes. It has long been believed that the abnormal function of adipocytes in obese patients i...

Claims

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Application Information

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IPC IPC(8): A61K48/00A61K38/16A61K38/10A61P3/10
Inventor 郭锡熔刘峰倪毓辉龚海霞辜楠范红旗陈荣华彭宇竹邱洁张敏王玢池霞费莉潘晓勤郭梅钱玲梅夏黎顾筱琪韩树萍刘茹童梅玲
Owner 郭锡熔
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