Nano target medicine for magnetothermal therapy of malignant tumor

Abstract

The invention relates to a method for preparing the nanometer target drug used to treat cancer. Wherein, it is a nanometer magnetic-antibody / ligand drug and nanometer magnetic target drug used in cancer magnetic thermal treatment, with high specific thermal power; it comprises 1:0.0001-0.20 effective molecule and guide molecule, while the effective molecule is magnetic powder whose diameter is lower than 1000nm, and the specific thermal power SAR is 10-7000W / gFe; the guide molecule comprises antibody or ligand or magnetic powder; the diameter of target drug is 2-1000nm; the preparation comprises that coupling the magnetic powder and guide molecule in water, organic or inorganic mixture. The inventive drug can effective kill cancer cell and treat cancer.

Description

Nano-targeted drugs for magnetic hyperthermia therapy of malignant tumors technical field The invention relates to a nano-targeted drug for magnetic hyperthermia therapy of malignant tumors and its preparation method and application, that is, a nano-magnetic powder-antibody / ligand targeted drug and nano-magnetic powder for magnetic hyperthermia therapy of malignant tumors with high heat-generating specific power Magnetically targeted drugs. Background technique In 2000, there were about 10 million new cases of malignant tumors in the world, 6.2 million deaths, and 22 million current cases. It is estimated that in 2020, there will be 15 million new cases of malignant tumors, 10 million deaths, and 30 million existing cases. Malignant tumors are becoming the number one killer of human beings in the new century, and will cause huge losses to the global social economy. It is of great significance to carry out research on new drugs and new treatment methods for malignant tumor...

AI Technical Summary

Problems solved by technology

But so far, magnetic thermal seeds still need to be introduced into tumor lesions by implantation, local injection, etc. in magnetic hyperthermia, and it has not been seen to couple antibodies or ligands with magnetic thermal seeds (i.e., nano-magnetic powder) to make active magnetothermal therapy. Targeted drugs and the use of the magnetic properties of magnetothermal seeds to make magnetically targeted drugs for magnetic hyperthermia and use the active and magnetic targeting functions of drugs to target drugs into tumor lesions for magnetic hyperthermia treatment of malignant tumors