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Application of extractive and effective parts of datura flower in preparing medication for anti tumor

A technology of anti-tumor drugs and effective parts, which is applied in the field of traditional Chinese medicine and can solve problems such as pharmacological research that does not describe therapeutic activity

Inactive Publication Date: 2007-05-09
卡南吉医药科技(上海)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Pharmacological studies of the therapeutic activity of the above-mentioned datura extracts in relation to malignancies are not described in the literature

Method used

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  • Application of extractive and effective parts of datura flower in preparing medication for anti tumor
  • Application of extractive and effective parts of datura flower in preparing medication for anti tumor
  • Application of extractive and effective parts of datura flower in preparing medication for anti tumor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Take 1 kg of Dajinhua, add 95% ethanol to reflux and extract for 2 hours each time, extract 3 times, combine the extracts, and evaporate the solvent to obtain 90 grams of Dajinhua extract.

Embodiment 2

[0059] Take 500 grams of Dajinhua, add 5 liters of petroleum ether, reflux and extract 3 times, each time for 1 hour, combine the extracts and concentrate to 50 milliliters to obtain the crude extract of Dajinhua oil, add 75 grams of activated carbon to the crude extract , stirred for 30 minutes, filtered and washed the activated carbon with ethyl acetate for 5 times, combined the filtrate and ethyl acetate washings, and evaporated the solvent to obtain refined datura oil.

Embodiment 3

[0061] 500 grams of datura flowers were extracted with CO2 supercritical, the extraction temperature was 35°C, the extraction pressure was 12Mpa, and the CO2 flow rate was 2.5kg / hr. After extraction in the separation tank for 240 minutes, the pressure of the separation tank was 8Mpa and the temperature was 40°C. The extract was placed in volatile oil In the separator, let it stand and centrifuge to obtain 4.6 grams of datura oil.

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Abstract

An application of the extract and active comonents of daturae flower in preparing the medicines for preventing and treating tumor, such as sarcoma and melanoma, is disclosed.

Description

Technical field: [0001] The invention belongs to the technical field of traditional Chinese medicine. Specifically, it relates to the application of the datura flower extract and the effective part of the datura flower in the preparation of antitumor drugs. Background technique: [0002] Tumor is a disease that seriously threatens human life and health. According to the World Health Organization survey, the proportion of cancer patients in the world accounts for about 6.89‰, while the number of new cancer patients is 1.78‰ every year, and the number of survivors is nearly 40 million. According to statistics from the Ministry of Health, the prevalence of malignant tumors in China has reached 1.15-1.27‰, and the death due to malignant tumors ranks second among all causes of death. Although great progress has been made in the treatment of malignant tumors, there is still a lack of ideal therapeutic drugs to meet clinical needs. Malignant tumors are still regarded as refractory...

Claims

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Application Information

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IPC IPC(8): A61K36/81A61P35/00
Inventor 王晓川吴威巍王作鹏
Owner 卡南吉医药科技(上海)有限公司
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