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Compound taxus chinensis capsule, preparation method and application of compound taxus chinensis capsule for treating qi deficiency and phlegm stasis in breast cancer chemotherapy

A technology of compound yew and yew, which is applied in capsule delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problem of low utilization rate of the whole plant, achieve strong anti-tumor effect, obvious anti-tumor effect, The effect of improving mental state

Inactive Publication Date: 2021-12-31
重庆赛诺生物药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Paclitaxel in natural yew trees is generally distributed in the bark, and the utilization rate of the whole plant is low

Method used

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  • Compound taxus chinensis capsule, preparation method and application of compound taxus chinensis capsule for treating qi deficiency and phlegm stasis in breast cancer chemotherapy
  • Compound taxus chinensis capsule, preparation method and application of compound taxus chinensis capsule for treating qi deficiency and phlegm stasis in breast cancer chemotherapy
  • Compound taxus chinensis capsule, preparation method and application of compound taxus chinensis capsule for treating qi deficiency and phlegm stasis in breast cancer chemotherapy

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The preparation of embodiment 1 experimental sample

[0032] (1) Supercritical extraction: the yew is crushed through a 20-60 mesh sieve, and the 2 Supercritical extraction, using 80-90% ethanol as entrainer (the ratio of yew to ethanol is 1:2 to 1:3 (m / v)), the extraction temperature is 40-60°C, the extraction pressure is 20-40MPa, the extraction time For 60-120 minutes, 40-60 ° C under reduced pressure to recover ethanol.

[0033] (2) Dichloromethane extraction: add water and dichloromethane to the concentrated extract, stir and mix thoroughly, separate and collect the dichloromethane liquid after standing for 4 hours, extract the water liquid with dichloromethane liquid for 3 times, and combine dichloromethane The methane liquid was filtered, and the dichloromethane was recovered under reduced pressure.

[0034] (3) Percolation of n-hexane and dichloromethane: the residue is dissolved in a mixed solution of ethyl acetate-methanol (3:1), mixed with diatomaceous eart...

Embodiment 2

[0038] Example 2 The synergistic effect of radiotherapy on tumor-bearing animals (Balb / c mice, 4T1 transplanted breast cancer) 1 to Co 60 Synergistic effect of irradiation (10Gy dose) (a total of two experiments)

[0039] 1.1 Experimental method

[0040] Cell suspension preparation and tumor inoculation:

[0041] Animal grouping and dosing: The mice were given a 10Gy dose of Co 60 irradiated (the model group was not irradiated), and then the mice were divided into 6 groups according to body weight, namely Co 60 Irradiation (10Gy dose) + compound yew capsule 740, 370, 185mg / kg, Co 60 Irradiation (10Gy dose) + compound mylabris capsule 308mg / kg, Co 60 Irradiation (10Gy dose) group and model control group. There were 20 rats in each group in the model control group, and 10 rats in each group in the treatment group. On the second day after inoculation, the corresponding drugs were given according to the group, Co 60 The irradiation (10Gy dose) group and the model control gr...

Embodiment 3

[0094] Example 3 for Co 60 Synergistic effect of irradiation (5Gy dose) (a total of two experiments)

[0095] 2.1 Experimental method

[0096] Cell suspension preparation and tumor inoculation.

[0097] Animal grouping and administration: The mice were given a dose of 5Gy Co on the second day after inoculation 60 irradiated (the model group was not irradiated), and then the mice were divided into 6 groups according to body weight, namely Co 60 Irradiation (5Gy dose) + compound yew capsule 740, 370, 185mg / kg, Co 60 Irradiation (5Gy dose) + compound mylabris capsule 308mg / kg, Co 60 Irradiation (5Gy dose) group and model control group. There were 20 rats in each group in the model control group, and 10 rats in each group in the treatment group. On the second day after inoculation, the corresponding drugs were given according to the group, Co 60 The irradiation (5Gy dose) group and the model control group were given purified water at a volume of 0.2ml / 10g body weight, once ...

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Abstract

The invention provides a compound taxus chinensis capsule, a preparation method and application of the compound taxus chinensis capsule for treating qi deficiency and phlegm stasis in breast cancer chemotherapy. Wherein the compound taxus chinensis capsule is prepared by mixing a taxus chinensis extract, a red ginseng extract and a liquorice extract. The preparation method adopts a supercritical extraction method. Technical improvement is carried out on the basis of an existing variety, and the technically improved compound taxus chinensis capsule has remarkable activity in maintenance treatment of stable recurrence rejection and / or metastatic advanced triple-negative breast cancer after first-line chemotherapy for 6-8 cycles and drug resistance (qi deficiency and phlegm stasis) of endocrine treatment with positive hormone receptors, and the existing technical blank is filled.

Description

technical field [0001] The invention relates to a kind of traditional Chinese medicine, in particular to a compound yew capsule, a preparation method and its application in chemotherapy of breast cancer with qi deficiency and phlegm stasis. [0002] technical background [0003] There are eleven species of yews in the world. At present, there are four species and one variety in my country, namely, Yunnan yew, Tibetan yew, northeast yew, Chinese yew and southern yew (variety); Mandia yew is my country introduced from Canada in the mid-1990s. Mandia yew (Taxus madia) is native to the United States and Canada. It is a natural hybrid variety. Its female parent is Northeast yew (T.cuspidata) and its male parent is European yew (T.bauata). It has been grown and developed in the United States and Canada for nearly 100 years. In the mid-1990s, the saplings of Taxus chinensis imported from China were planted in Sichuan for trial planting. The biological characteristics of the introdu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/484A61K36/13A61K9/48A61K45/06A61K31/675A61P35/00A61P35/04
CPCA61K36/13A61K36/258A61K36/484A61K9/1611A61K45/06A61K31/675A61P35/00A61P35/04A61K2236/37A61K2236/333A61K2236/51A61K2236/55A61K2300/00
Inventor 刘悉承
Owner 重庆赛诺生物药业股份有限公司
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