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Pharmaceutical composition for treating angina pectoris and preparation method thereof

A technology of coronary heart disease angina pectoris and composition, which is applied in the field of pharmaceutical composition for treating coronary heart disease angina pectoris, can solve problems such as not being able to meet clinical needs, achieve the effects of improving electrocardiogram, taking conveniently, and improving symptoms

Inactive Publication Date: 2007-05-16
CHENGZHENG XINKAI PHARMA FACTORY SUZHOU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

New drugs for the treatment of coronary heart disease are being introduced continuously, but they still cannot meet the clinical needs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] ① Take 325g of Jiangxiang, 325g of Schisandra, and 162g of Asarum, soak in water for 12 hours, and extract the volatile oil with an oil extractor for 8 hours to obtain the volatile oil and water extract, and set aside;

[0035] ② Take 487g of Salvia miltiorrhiza, 325g of Chuanxiong, and 325g of safflower, add 95% ethanol to extract twice, each time for 1-2 hours, combine the extracts, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.28;

[0036]③Merge the medicinal dregs in step ② with 487g Polygonum multiflorum, 487g Polygonatum Polygonatum, and 325g Poria cocos, add water to decoct twice, each time for 1-2 hours, combine the decoction, let stand, take the supernatant, and mix with the decoction in step ① Combine the water extracts, concentrate under reduced pressure to a relative density of 1.06, add high-concentration ethanol to contain 70% alcohol, stir, let stand overnight, filter, and concentrate the filtrate under reduced pres...

Embodiment 2

[0039] ①Take 260g of Jiangxiang, 260g of Schisandra, and 97g of Herba Asarum, soak in water for 12 hours, extract the volatile oil with an oil extractor for 8 hours, and obtain the volatile oil and water extract for later use;

[0040] ② Take 617g of Salvia miltiorrhiza, 260g of Chuanxiong, and 260g of safflower, add 95% ethanol to extract twice, each time for 1-2 hours, combine the extracts, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.28;

[0041] ③Merge the medicinal dregs in step ② with 617g Polygonum multiflorum, 617g Polygonatum Polygonatum, and 260g Poria cocos, add water to decoct twice, each time for 1-2 hours, combine the decoction, let stand, take the supernatant, and mix with the decoction in step ① Combine the water extracts, concentrate under reduced pressure to a relative density of 1.06, add high-concentration ethanol to contain 70% alcohol, stir, let stand overnight, filter, and concentrate the filtrate under reduced pr...

Embodiment 3

[0044] ① Take 280g of Jiangxiang, 280g of Schisandra, and 168g of Herba Asarum, soak in water for 12 hours, extract the volatile oil with an oil extractor for 8 hours, and obtain the volatile oil and water extract for later use;

[0045] ② Take 560g of Salvia miltiorrhiza, 280g of Chuanxiong, and 280g of safflower, add 95% ethanol to extract twice, each time for 1-2 hours, combine the extracts, filter, and concentrate the filtrate under reduced pressure below 60°C to a relative density of 1.28;

[0046] ③Merge the medicinal residues in step ② with 560g Polygonum multiflorum multiflorum, 560g Polygonatum Polygonatum, and 280g Poria cocos, add water to decoct twice, each time for 1-2 hours, combine the decoction, let stand, take the supernatant, and mix with the decoction in step ① Combine the water extracts, concentrate under reduced pressure to a relative density of 1.06, add high-concentration ethanol to contain 70% alcohol, stir, let stand overnight, filter, and concentrate t...

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PUM

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Abstract

The invention relates to a drug compound for treating coronary disease and angina pectoris, wherein its active components comprise 11 traditional medicines as Danshen and chuanxiong rhizome; first using 3 traditional medicines to extract volatile oil and water extractive; then using another three traditional medicines to extract with dissolvent, depressurizing and concentrating to obtain mellow extractive; combining the slag and another three traditional medicines, extracting, combining the clean solution and said extractives, depressurizing and concentrating, to be combined with mellow extractive; depressurizing, drying to obtain dry paste; then adding the last two traditional medicines and the volatile oil, drying to obtain particles. The invention can treat coronary disease and angina pectoris.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating angina pectoris of coronary heart disease and a preparation method thereof. Background technique [0002] Cardiovascular disease is a disease with very high morbidity and mortality. It has recently been found that the age of onset of coronary heart disease presents a younger trend. With the improvement of living standards, changes in dietary structure and ecological environment, the incidence and mortality of coronary heart disease are on the rise. Therefore, the research on drugs for the prevention and treatment of coronary heart disease And development has always been concerned by governments and medical workers. New drugs for the treatment of coronary heart disease are constantly released, but they still cannot meet the clinical needs. Contents of the invention [0003] The purpose of the present invention is to provide a pharmaceutical composition for treating angina pectoris of...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61K9/16A61K9/20A61K9/48A61P9/10
Inventor 魏吉城孔伶俐张孝清夏春英孙卫董怡阎政冯志英刘志祥王金陵
Owner CHENGZHENG XINKAI PHARMA FACTORY SUZHOU
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