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Devices and methods for promoting transcutaneous movement of substances

a technology of substances and devices, applied in the field of compound delivery, can solve the problems of affecting the permeation of molecules through the membrane, the dependence of the diffusion coefficient, and the influence of molecules on the permeation of molecules, so as to increase the permeability of the layer, increase the activity of both lymphatics, and efficiently permeate the

Inactive Publication Date: 2005-03-10
GIAMMARUSTI PEDRO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0033] An object of the present invention is to provide a method for fast active transcutaneous permeation of compounds through the human skin targeting obtaining either local or systemic results allowing,among others, the non-invasive painless treatment of cellulitis, localized fat, stretch marks and flacid skin.
[0035] A further object of the invention is to minimize the time of treatment through the synergetic simultaneous use of both chemical enhancers and several physical principles.
[0038] Ultrasound energy also may also open up diffusional pathways in the stratum corneum, causing an increase in the permeability of that layer and causing frictional heat to be generated in deeper tissues, increasing the activity of both lymph and blood circulation, as well as of metabolic processes.

Problems solved by technology

One important issue to be remebered is that the diffusion coefficient is strongly dependent on the degree of hydration of the skin, significantly increasing with it.
Further, the choice of solvents and media containing the molecules also affects permeation of the molecules through the membranes.

Method used

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  • Devices and methods for promoting transcutaneous movement of substances
  • Devices and methods for promoting transcutaneous movement of substances
  • Devices and methods for promoting transcutaneous movement of substances

Examples

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Embodiment Construction

[0053] Although the present invention, as described herein, presents the best approach presently known for enhancing the permeability of membranes using ultrasound and enhancing the transcutaneous flux rate of a compound through a biological membrane through the use of chemical permants and iontophoresis, electroporation, mechanical vibrations and magnetophoreis, it is to be understood that this invention is not limited to the particular process steps and materials disclosed herein as such process steps and materials may vary.

[0054] It is also to be understood that the terminology used herein is not intended to be limiting since the scope of the present invention will be limited only by the appended claims and their equivalents.

[0055] This invention is intended to establish an optimized mode of delivery of agents or permeants which exist in the state of the art or which may later be established as active agents and which are suitable for delivery by the present invention, includin...

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Abstract

A non-invasive method of enhancing the permeability of the skin to a biologically active permeant or compound is described utilizing a combination of sonophoresis and chemical enhancers. Synergism brought simultaneously applying iontophoresis, electroporation, mechanical vibrations and magnetophoresis is used to optimize the transcutaneous active permeation of compounds, considerably lowering the time of treatment.The method is intended also for, among others, the non-invasive painless treatment of cellulitis, localized fat stretch marks and flacid skin.

Description

BACKGROUND OF THE INVENTION [0001] This invention relates generally to the field of compound delivery for obtaining both local and systemic results. More particularly, it relates to a non-invasive method of compound delivery through the epidermis by means of increasing the permeability of skin through the use of chemical enhancers and sonophoresis and the synergetic simultaneous use of iontophoresis, electroporation, mechanical vibrations and magnetophoresis for optimizing transcutaneous compound delivery into the body. [0002] The human skin has barrier properties and stratum corneum is mostly responsible for them, thus it is exactly the statum corneum, the outer horny layer of the skin, that imposes the greatest barrier to transcutaneous flux of compounds into the body. [0003] The low permeability attributed to the stratum corneum, a complex structure comprised of multi-layered compact keratinized cells; low permeability is due to dead cells filled with keratin fibers (keratinocyte...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61M31/00A61N1/32
CPCA61M31/002A61N1/325A61M2037/0007
Inventor GIAMMARUSTI, PEDRO
Owner GIAMMARUSTI PEDRO
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