Devices and methods for promoting transcutaneous movement of substances

a technology of substances and devices, applied in the field of compound delivery, can solve the problems of affecting the permeation of molecules through the membrane, the dependence of the diffusion coefficient, and the influence of molecules on the permeation of molecules, so as to increase the permeability of the layer, increase the activity of both lymphatics, and efficiently permeate the
US20050054970A1Inactive Publication Date: 2005-03-10GIAMMARUSTI PEDRO
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
GIAMMARUSTI PEDRO
Publication Date
2005-03-10
Estimated Expiration
Not applicable · inactive patent

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Abstract

A non-invasive method of enhancing the permeability of the skin to a biologically active permeant or compound is described utilizing a combination of sonophoresis and chemical enhancers. Synergism brought simultaneously applying iontophoresis, electroporation, mechanical vibrations and magnetophoresis is used to optimize the transcutaneous active permeation of compounds, considerably lowering the time of treatment.The method is intended also for, among others, the non-invasive painless treatment of cellulitis, localized fat stretch marks and flacid skin.
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Description

BACKGROUND OF THE INVENTION

[0001] This invention relates generally to the field of compound delivery for obtaining both local and systemic results. More particularly, it relates to a non-invasive method of compound delivery through the epidermis by means of increasing the permeability of skin through the use of chemical enhancers and sonophoresis and the synergetic simultaneous use of iontophoresis, electroporation, mechanical vibrations and magnetophoresis for optimizing transcutaneous compound delivery into the body.

[0002] The human skin has barrier properties and stratum corneum is mostly responsible for them, thus it is exactly the statum corneum, the outer horny layer of the skin, that imposes the greatest barrier to transcutaneous flux of compounds into the body.

[0003] The low permeability attributed to the stratum corneum, a complex structure comprised of multi-layered compact keratinized cells; low permeability is due to dead cells filled with keratin fibers (keratinocyte...

Claims

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