Use of creatine analogues and creatine kinase modulators for the prevention and treatment of obesity and its related disorders

a technology of creatine kinase and creatine analogue, which is applied in the direction of drug composition, peptide/protein ingredient, metabolic disorder, etc., can solve the problems of increased mortality rate, increased risk of cardiovascular disease, hypertension, diabetes, etc., and achieves severe weight loss and imbalanced energy expenditure. , the effect of increasing the risk of cardiovascular diseas
US20090298943A1Inactive Publication Date: 2009-12-03AVICENA GROUP
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
AVICENA GROUP
Publication Date
2009-12-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to the use of creatine compounds for treating or preventing a metabolic disorder related to body weight control such as obesity, and it's associated diseases in a patient experiencing said disorder. The creatine compounds which can be used in the present method include (1) analogues of creatine which can act as substrates or substrate analogues for the enzyme creatine kinase; (2) compounds which can act as inhibitors of creatine kinase; (3) compounds which can modulate the creatine transporter (4) N-phosphocreatine analogues bearing transferable or non-transferable moieties which mimic the N-phosphoryl group. (5) compounds which modify the association of creatine kinase with other cellular components.
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Description

RELATED APPLICATIONS

[0001] The present application is a continuation-in-part of and claims priority to Provisional Application U.S. Ser. No. 60 / 005,882, filed Oct. 26, 1995, the entire disclosure of which is incorporated herein by reference.FIELD OF INVENTION

[0002] The present invention provides for new use for creatine compounds (creatine analogues and compounds which modulate one or more of the structural or functional components of the creatine kinase / creatine phosphate system) as therapeutic agents. More particularly, the present invention provides a method of treating or preventing certain metabolic disorders of human and animal metabolism relating to aberrant body weight regulation as manifested in obesity and it's related disorders.BACKGROUND OF THE INVENTION

[0003] There are several metabolic diseases of human and animal metabolism, eg., obesity and severe weight loss that relate to energy imbalance—where caloric intake versus energy expenditure—is imbalanced. Obesity, which can...

Claims

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