Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses

Abstract

The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation of U.S. application Ser. No. 12 / 387,959, filed on May 8, 2009 (published), which is a continuation of U.S. application Ser. No. 10 / 741,790, filed on Dec. 19, 2003 (now U.S. Pat. No. 7,547,766), which is a continuation of U.S. application Ser. No. 09 / 759,130, filed Jan. 12, 2001 (now abandoned).[0002]U.S. application Ser. No. 09 / 759,130, is a continuation-in-part of U.S. application Ser. No. 09 / 479,249, filed on Jan. 7, 2000 (abandoned), and a continuation-in-part of U.S. application Ser. No. 09 / 559,497, filed on Apr. 27, 2000 (abandoned).[0003]U.S. application Ser. No. 09 / 759,130, is also a continuation-in-part of U.S. application Ser. No. 09 / 578,063, filed on May 24, 2000 (now U.S. Pat. No. 6,764,677), which is a continuation-in-part of U.S. application Ser. No. 09 / 333,159, filed on Jun. 14, 1999 (now U.S. Pat. No. 7,033,780).[0004]U.S. application Ser. No. 09 / 759,130, is also a continuation-in-part of ...

AI Technical Summary

Benefits of technology

[0044]INTERCEPT 217 polypeptides, nucleic acids, and modulators thereof exhibit the ability to affect growth, proliferation, survival, differentiation, and activity of human pancreas, skeletal muscle, heart, brain, placenta, lung, liver, and kidney cells. INTERCEPT 217 modulates cellular binding to one or more mediators, modulates activity and release of one or more pancreatically secreted digestive enzymes, and protects tissue from endogenous digestive enzymes. INTERCEPT 217 polypeptides, nucleic acids, and modulators thereof can be used to prevent, diagnose, or treat disorders relating to aberrant endogenous digestive enzyme activity, inappropriate interaction (or non-interaction) of cells with mediators, inappropriate cellular development and proliferation, inappropriate inflammation, and inappropriate immune responses.

[0047]TANGO 292 polypeptides, nucleic acids, and modulators thereof modulate growth, proliferation, survival, differentiation, and activity of human keratinocytes, including embryonic keratinocytes. TANGO 292, a transmembrane protein, is also involved in binding and uptake of calcium and other metal ions, and in responses of cells which express it to the presence and uptake of such ions. TANGO 292 polypeptides, nucleic acids, and modulators can be used to prevent, diagnose, and treat disorders involving one or more of bone uptake, maintenance, and deposition, formation, maintenance, and repair of cartilage and skin, formation and maintenance of extracellular matrices, movement of cells through extracellular matrices, coagulation and dissolution of blood components, and deposition of materials in and on arterial walls.

Problems solved by technology

In the past, the complexity of biological systems overwhelmed the ability of practitioners to understand the molecular interactions giving rise to normal and abnormal physiological states.

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