Method of making dialkyl sulfosuccinate compositions

Abstract

A particulate solid composition comprises a blend of dialkyl sulfosuccinate and a water-soluble polymer. The water-soluble polymer can be a cellulose ether, a polysaccharide, a polyvinyl alcohol homopolymer or copolymer, a polyvinyl pyrrolidone homopolymer or copolymer, a polyvinyl caprolactam polymer or copolymer, a poly(meth)acrylate, a poly(alkylene oxide) graft copolymer, or a combination thereof. The particulate solid composition is free flowing, water-soluble, and dissolves rapidly in water. It can be made by drying a solution of dialkyl sulfosuccinate and a water-soluble polymer. The particulate solid composition can be mixed with organic substances having low water solubility, for example a generic, a biologic, a biosimilar, an excipient, a nutraceutical, a medical diagnostic agent, an agricultural chemical, or a combination thereof, to form water-soluble compositions.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application is a divisional of U.S. application Ser. No. 15 / 046,648, filed Feb. 18, 2016 (allowed), which claims priority to U.S. Provisional Application Nos. 62 / 287,198, filed Jan. 26, 2016 (expired), and 62 / 118,786, filed Feb. 20, 2015 (expired), each of which is incorporated herein by reference in their entirety.BACKGROUND OF THE INVENTION[0002]Dialkyl sulfosuccinates are a class of surfactants used as emulsifiers, dispersants, wetting agents, and adjuvants. An example of a dialkyl sulfosuccinate is sodium dioctyl sulfosuccinate (DOSS). DOSS is a waxy, sticky, granular solid, which is difficult to handle. It tends to form lumps upon storage, and is slow to dissolve in solvents. Therefore it is often supplied in solution form, dissolved in organic solvent, water, or organic solvent-water combinations, for example ethanol-water and propylene glycol-water. DOSS can also be mixed with a solid diluent, for example sodium benzoate (SB),...

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