Blood biomarkers and diagnostic methods for small vessel diseases

a blood biomarker and small vessel technology, applied in the field of therapeutics and diagnostics can solve the problems of difficult detection, no diagnostic or prognostic biomarkers for small vessel diseases,

Inactive Publication Date: 2020-04-02
THE SCHEPENS EYE RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0068]In instances where an SVD cannot be specifically treated, the diagnostic and prognostic methods of the present subject matter provide valuable information to subjects that will allow them t

Problems solved by technology

Currently, there are no diagnostic or prognostic biomarkers for small vessel diseases (SVDs).
The condition is treat

Method used

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  • Blood biomarkers and diagnostic methods for small vessel diseases
  • Blood biomarkers and diagnostic methods for small vessel diseases
  • Blood biomarkers and diagnostic methods for small vessel diseases

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Experimental program
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Effect test

embodiments

[0303]Embodiments include Embodiments P1 to P40 following.

embodiment p1

[0304]A method for diagnosing a small vessel disease (SVD) in a subject in need thereof comprising[0305](a) providing a test sample from said subject;[0306](b) assaying the level of endostatin, High-Temperature Requirement A Serine Peptidase 1 (HTRA1), insulin-like growth factor binding protein 1 (IGFBP-1), and / or Neurogenic Locus Notch Homolog Protein 3 (NOTCH3) in the test sample; and[0307](c) diagnosing the subject with the SVD if[0308](i) the level of endostatin, IGFBP-1, and / or HTRA1 is elevated in the test sample compared to a normal control, and / or[0309](ii) the level of NOTCH3 is reduced in the test sample compared to the normal control.

embodiment p2

[0310]The method of Embodiment P1, wherein said subject is diagnosed with the SVD if (i) the level of endostatin, IGFBP-1, and / or HTRA1 is at least about 5%, 10%, 15%, 20%, 25%, 30%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 90%, 5-50%, 50-75%, 1-fold, 2-fold, 3-fold, 4-fold, or 5-fold higher in said test sample compared to a normal control; and / or (ii) the level of NOTCH3 reduced by about 5%, 10%, 15%, 20%, 25%, 30%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 90%, 95%, 99%, 100%, 5-50%, 50-75%, or 75-100% in said test sample compared to a normal control.

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Abstract

The present subject matter provides, inter alia compositions, systems, kits and methods for diagnosing and treating small vessel diseases (SDVDs).

Description

RELATED APPLICATIONS[0001]This application claims the benefit of priority to U.S. Provisional Application No. 62 / 477,274, filed Mar. 27, 2017, the entire contents of which are incorporated herein by reference.STATEMENT AS TO FEDERALLY SPONSORED RESEARCH[0002]This invention was made with government support under R01EY005318 and R00EY021624 and P30EY003790 awarded by the National Institutes of Health. The government has certain rights in the invention.SEQUENCE LISTING[0003]Incorporated by reference in its entirety is a computer-readable nucleotide / amino acid sequence listing submitted concurrently herewith and identified as follows: 104,834 bytes bytes Text file named “36770-553001WO_Sequence_Listing_ST25.txt” created on Mar. 26, 2018.FIELD OF THE INVENTION[0004]The present invention relates to therapeutics and diagnostics for small vessel diseases.BACKGROUND[0005]Currently, there are no diagnostic or prognostic biomarkers for small vessel diseases (SVDs). SVDs include very prevalent ...

Claims

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Application Information

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IPC IPC(8): G01N33/68C07K16/28
CPCG01N2333/705G01N2333/65C07K16/28G01N2333/96433G01N33/6896G01N2800/042G01N2800/2871G01N2800/164G01N2800/56G01N2333/78G01N33/53
Inventor ARBOLEDA-VELASQUEZ, JOSEPH F.
Owner THE SCHEPENS EYE RES INST
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