Composition for enhancing immunity or preventing or treating neurodegenerative diseases by using goji berries, mulberries and jujubes

Inactive Publication Date: 2020-12-10
COSMAX NS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0020]The composition according to the present invention, which comprises a mixture extract of goji berries, mulberries and jujubes or an extract mixture thereof as an active ingredient, has a synergistic effect on the immune enhancement efficacy due to a combination of goji berry, mulberry and jujube and thus it can be usefully used as a pharmaceutical composition or a health functional food without cytotoxicity. In particular, when the weight ratio of goji berry, mulberry and jujube is 1 to 3:1 to 3:0.5 to 1.5, or when the mixture extract or the extract mixture is lyophilized, it is possible to further improve the immune enhancement efficacy.
[0021]In

Problems solved by technology

Researches to show the immune enhancement efficacy through these macrophages or to prevent, treat or ameliorate neurodegenerative disease

Method used

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  • Composition for enhancing immunity or preventing or treating neurodegenerative diseases by using goji berries, mulberries and jujubes
  • Composition for enhancing immunity or preventing or treating neurodegenerative diseases by using goji berries, mulberries and jujubes
  • Composition for enhancing immunity or preventing or treating neurodegenerative diseases by using goji berries, mulberries and jujubes

Examples

Experimental program
Comparison scheme
Effect test

Example

Example 1

[0086]About 40 g of goji berries (origin: China), about 40 g of mulberries (origin: Pakistan), and about 20 g of jujubes (origin: Korea) were mixed to prepare a mixture. The prepared mixture was mixed with 10 (v / w) times water. The mixture was extracted under reflux at 95° C. for 4 hours, filtered under reduced pressure, and concentrated in a rotary vacuum concentrator to prepare a mixture extract. Then, it was lyophilized for 72 hours at −40° C.

Example

Example 2

[0087]About 40 g of goji berries (origin: China), about 40 g of mulberries (origin: Pakistan), and about 20 g of jujubes (origin: Korea) were mixed to prepare a mixture. The prepared mixture was mixed with 10 (v / w) times water. The mixture was extracted under reflux at 95° C. for 4 hours, filtered under reduced pressure, and concentrated in a rotary vacuum concentrator to prepare a mixture extract. Then, it was mixed with 50% by weight of dextrin and spray dried.

Example

Comparative Example 1

[0088]Goji berries (origin: China) were mixed with 10 (v / w) times water, and the mixture was extracted under reflux for 4 hours at 95° C. Thereafter, it was filtered under reduced pressure, and concentrated in a rotary vacuum concentrator to prepare a single extract. Then, it was mixed with 50% by weight of dextrin and spray dried.

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Abstract

The present invention relates to a composition for enhancing immunity or a composition for preventing or ameliorating neurodegenerative diseases, both of which contain, as an active ingredient, a mixture extract of goji berries, mulberries and jujubes or an extract mixture thereof.

Description

BACKGROUND OF THE INVENTION1. Field of the Invention[0001]The present invention relates to a composition for enhancing immunity or preventing or ameliorating neurodegenerative diseases, which comprises a mixture extract of goji berries, mulberries and jujubes or an extract mixture thereof.2. Description of the Related Art[0002]Macrophage is a cell that regulates immune phenomena by secreting various materials in the process of phagocytosis and removal of bacteria or foreign substances and plays a pivotal role in the immune response to antigens, and involves in antigen presentation and non-specific immune response of lymphocytes, and has direct injury activity against tumor cells. In addition, it is known substances (LPS or natural products) responding to toll-like receptors (TLR) activate macrophages to produce cytokines such as IL-1, IL-6, IL-10, 1L-12 and TNF-α which can regulate secondary immune responses such as defense against microbial infection, activation of macrophages for ...

Claims

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Application Information

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IPC IPC(8): A61K36/815A61K36/605A61K36/725A23L33/105
CPCA61K36/605A61K2236/51A61K36/815A61K36/725A23L33/105A23V2002/00A23V2200/322A23V2200/324A61P25/00A61P37/00A61K2236/00A61K2300/00
Inventor BAEK, KWANG SOOKIM, HYUNJICHOI, SU YOUNGKIM, JIN HAKSHIM, JAE SEOKPARK, YOUNG MINKIM, SANG WOOYOON, MANN-SEOKLEE, YOON JONG
Owner COSMAX NS INC
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