Novel class of sequence-defined polymers and preparation methods thereof
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example 1
of a 9-Mer (V) of Sequence-Defined Polymer where, R1 is Phenyl Group, R2 is Cyclohexyl Group, R3 is Butyl Group, R4 is Benzyl Group, and R5 is Diethyl Amine Group
[0052]
[0053]Step (a): Synthesis of N, N-diphenyl chloroacetyl amide (2-mer): N, N-Diphenyl amine (1 mmol) was reacted with chloroacetyl chloride (1.5 mmol) in 5 ml of dichloromethane (DCM) and triethylamine. The reaction was carried out at 0° C. for initial 10 min, then the reaction mixture was brought to room temperature and continued for 1 hour at room temperature. After completion of the reaction (monitored by TLC), the excess chloroacetyl chloride was quenched by the addition of sodium bicarbonate (NaHCO3). The reaction mixture was extracted in 1:1 ethyl acetate / water, ethyl acetate layer was dried in anhydrous Na2SO4 and the product was isolated from ethyl acetate layer. The solvent was removed under reduced pressure and the product was used for the next step reaction without further purification.
[0054]Step (b): Synthe...
example 2
of 9-Mer (Va) with R1=Diethyl Amine, R2=Butyl, R3=Cyclohexyl, R4=Benzyl, R5=Pyridine
[0062]
[0063](a) Synthesis of N,N-Diethyl Chloroacetyl Amide (2-Mer):
[0064]N,N-Diethyl amine (1 mmol) was reacted with chloroacetyl chloride (1.5 mmol) in 5 ml of dichloromethane (DCM) and triethylamine. The reaction was carried out at 0° C. for initial 10 min, then the reaction mixture was brought to room temperature and continued for 1 hour at room temperature. After completion of the reaction (monitored by TLC), the excess chloroacetyl chloride was quenched by the addition of sodium bicarbonate (NaHCO3). The reaction mixture was extracted in 1:1 ethyl acetate / water, ethyl acetate layer was dried in anhydrous Na2SO4 and the product was isolated from ethyl acetate layer.
[0065](b) Synthesis of 3-Mer:
[0066]2-mer (1 mmol), the butyl amine-hydroxyl monomer (2 mmol) and CS2 (4 mmol) were mixed in PEG-200 (1 mL). The reaction mixture was stirred at room temperature for 1 h. After completion of the reaction...
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