Oral gel containing rare saponins of Panax notoginseng and preparation method thereof

Abstract

The invention belongs to the technical field of chemical articles of everyday use, and particularly relates to oral gel containing radix-et-rhizoma-notoginseng rare saponin and a preparation method thereof. The oral gel containing the radix-et-rhizoma-notoginseng rare saponin, which is provided by the invention, is prepared from the following raw materials in parts by mass: 4 to 6 parts of radix-et-rhizoma-notoginseng rare saponin pre-confected emulsion, 0.3 to 0.5 part of chitosan oligosaccharide, 45 to 55 parts of glycerol, 12 to 18 parts of carbomer, 17 to 22 parts of poloxamer, 8 to 11 parts of herba-menthae essence, 0.7 to 1.2 parts of ethyl hydroxybenzoate, 0.2 to 0.4 part of disodium ethylenediaminotetraacetate, 5 to 7 parts of triethanolamine and 880 to 900 parts of purified water.The oral gel containing the radix-et-rhizoma-notoginseng rare saponin, which is provided by the invention, has favorable bacteriostatic and pain-relieving effects, can be used for removing gingival swelling and pain, gingivitis and periodontitis, has favorable cleaning and nursing effects, and is used for enabling an oral cavity to be more healthier, and in addition, the oral gel containing the radix-et-rhizoma-notoginseng rare saponin, which is provided by the invention, is high in safety and is suitable to use for a long time.

Description

technical field

[0001] The invention belongs to the technical field of daily chemical products, and in particular relates to an oral gel containing rare saponins of notoginseng and a preparation method thereof. Background technique

[0002] The frequently-occurring diseases (caries, gingivitis, periodontitis) that occur in the oral cavity all belong to bacterial infectious diseases, and the pathogenic bacteria are common bacteria in the human oral cavity. Under normal circumstances, various microorganisms maintain a dynamic balance; under abnormal circumstances, the flora is out of balance, and certain pathogenic bacteria overgrow and cause diseases. Long-term use of broad-spectrum antibiotics and chemical synthetic drugs destroys the oral microecological balance while eliminating pathogenic bacteria. The exploration and application of plant-based substances with antibacterial activity has become a common goal pursued by medical scientists today.

[0003] Panax notoginseng...

Examples

Embodiment 1

[0034] Embodiment 1, a kind of oral gel containing notoginseng rare saponins

[0035] The oral gel containing the rare saponins of Panax notoginseng consists of the following raw materials and their mass parts:

[0036] 4 parts of Panax notoginseng rare saponin pre-mixed milk, 0.3 parts of chitosan oligosaccharide with an average molecular weight of 1000, 45 parts of glycerin, 12 parts of carbomer 981NF, 40717 parts of poloxamer, 8 parts of mint essence, 0.7 parts of ethyl paraben , 0.2 parts of disodium edetate, 5 parts of triethanolamine and 880 parts of purified water.

[0037] The preparation method of the Panax notoginseng rare saponin premixed milk is:

[0038](1) Crush Panax notoginseng and pass through a 20-mesh sieve to obtain Panax notoginseng powder, add petroleum ether with 4 times the mass of the above-mentioned Panax notoginseng powder, stir at a speed of 300r / min, stir for 4h, let stand for 1h, remove the upper liquid , add petroleum ether with 3 times the mas...

Embodiment 2

[0046] Embodiment 2, a kind of oral gel containing the rare saponins of Panax notoginseng

[0047] The oral gel containing the rare saponins of Panax notoginseng consists of the following raw materials and their mass parts:

[0048] 6 parts of Panax notoginseng rare saponin pre-mixed milk, 0.5 parts of chitosan oligosaccharide with an average molecular weight of 3000, 55 parts of glycerin, 18 parts of carbomer 981NF, 40722 parts of poloxamer, 11 parts of mint essence, 1.2 parts of ethyl paraben , 0.4 parts of disodium edetate, 7 parts of triethanolamine and 900 parts of purified water.

[0049] The preparation method of the Panax notoginseng rare saponin premixed milk is similar to that of Example 1.

[0050] The preparation method of the oral gel containing the rare saponins of Panax notoginseng, the steps are as follows:

[0051] S1 Take carbomer, add purified water, the amount of purified water added is 28 times the mass of the above-mentioned carbomer, stir evenly, let s...

Embodiment 3

[0056] Embodiment 3, a kind of oral gel containing the rare saponins of Panax notoginseng

[0057] The oral gel containing the rare saponins of Panax notoginseng consists of the following raw materials and their mass parts:

[0058] 5 parts of Panax notoginseng rare saponin pre-mixed milk, 0.4 parts of chitosan oligosaccharide with an average molecular weight of 2000, 50 parts of glycerin, 15 parts of carbomer 981NF, 40720 parts of poloxamer, 10 parts of mint essence, 1 part of ethyl paraben , 0.3 parts of disodium edetate, 6 parts of triethanolamine and 892.7 parts of purified water.

[0059] The preparation method of the Panax notoginseng rare saponin premixed milk is similar to that of Example 1.

[0060] The preparation method of the oral gel containing the rare saponins of Panax notoginseng, the steps are as follows:

[0061] S1 Take carbomer, add purified water, the amount of purified water added is 26 times the mass of the above-mentioned carbomer, stir evenly, let st...

technical field

[0001] The invention belongs to the technical field of daily chemical products, and in particular relates to an oral gel containing rare saponins of notoginseng and a preparation method thereof. Background technique

[0002] The frequently-occurring diseases (caries, gingivitis, periodontitis) that occur in the oral cavity all belong to bacterial infectious diseases, and the pathogenic bacteria are common bacteria in the human oral cavity. Under normal circumstances, various microorganisms maintain a dynamic balance; under abnormal circumstances, the flora is out of balance, and certain pathogenic bacteria overgrow and cause diseases. Long-term use of broad-spectrum antibiotics and chemical synthetic drugs destroys the oral microecological balance while eliminating pathogenic bacteria. The exploration and application of plant-based substances with antibacterial activity has become a common goal pursued by medical scientists today.

[0003] Panax notoginseng...

Examples

Embodiment 1

[0034] Embodiment 1, a kind of oral gel containing notoginseng rare saponins

[0035] The oral gel containing the rare saponins of Panax notoginseng consists of the following raw materials and their mass parts:

[0036] 4 parts of Panax notoginseng rare saponin pre-mixed milk, 0.3 parts of chitosan oligosaccharide with an average molecular weight of 1000, 45 parts of glycerin, 12 parts of carbomer 981NF, 40717 parts of poloxamer, 8 parts of mint essence, 0.7 parts of ethyl paraben , 0.2 parts of disodium edetate, 5 parts of triethanolamine and 880 parts of purified water.

[0037] The preparation method of the Panax notoginseng rare saponin premixed milk is:

[0038](1) Crush Panax notoginseng and pass through a 20-mesh sieve to obtain Panax notoginseng powder, add petroleum ether with 4 times the mass of the above-mentioned Panax notoginseng powder, stir at a speed of 300r / min, stir for 4h, let stand for 1h, remove the upper liquid , add petroleum ether with 3 times the mas...

Embodiment 2

[0046] Embodiment 2, a kind of oral gel containing the rare saponins of Panax notoginseng

[0047] The oral gel containing the rare saponins of Panax notoginseng consists of the following raw materials and their mass parts:

[0048] 6 parts of Panax notoginseng rare saponin pre-mixed milk, 0.5 parts of chitosan oligosaccharide with an average molecular weight of 3000, 55 parts of glycerin, 18 parts of carbomer 981NF, 40722 parts of poloxamer, 11 parts of mint essence, 1.2 parts of ethyl paraben , 0.4 parts of disodium edetate, 7 parts of triethanolamine and 900 parts of purified water.

[0049] The preparation method of the Panax notoginseng rare saponin premixed milk is similar to that of Example 1.

[0050] The preparation method of the oral gel containing the rare saponins of Panax notoginseng, the steps are as follows:

[0051] S1 Take carbomer, add purified water, the amount of purified water added is 28 times the mass of the above-mentioned carbomer, stir evenly, let s...

Embodiment 3

[0056] Embodiment 3, a kind of oral gel containing the rare saponins of Panax notoginseng

[0057] The oral gel containing the rare saponins of Panax notoginseng consists of the following raw materials and their mass parts:

[0058] 5 parts of Panax notoginseng rare saponin pre-mixed milk, 0.4 parts of chitosan oligosaccharide with an average molecular weight of 2000, 50 parts of glycerin, 15 parts of carbomer 981NF, 40720 parts of poloxamer, 10 parts of mint essence, 1 part of ethyl paraben , 0.3 parts of disodium edetate, 6 parts of triethanolamine and 892.7 parts of purified water.

[0059] The preparation method of the Panax notoginseng rare saponin premixed milk is similar to that of Example 1.

[0060] The preparation method of the oral gel containing the rare saponins of Panax notoginseng, the steps are as follows:

[0061] S1 Take carbomer, add purified water, the amount of purified water added is 26 times the mass of the above-mentioned carbomer, stir evenly, let st...

Images