3 results about "Potassium channel activity" patented technology

The present invention relates to novel compounds, pharmaceutical compositions comprising such compounds and their use for treating, alleviating or preventing diseases or disorders relating to the activity of potassium channels.

The disclosure provides methods for the treatment of disorders associated with an increase in potassium channel activity using small molecule inhibitors, such as compounds that selectively bind to a Per-Arnt-Sim (PAS) domain of Ether-à-go-go 1 (EAG1) potassium channels. The disclosure also features pharmaceutical compositions comprising therapeutically effective amounts of the disclosed small molecule inhibitors.

This invention discloses a cell marker gene for maintaining the ion environment in silk-secreting insects. KCNQ Identification and application of marker genes for maintaining ion environment in silk-secreting insects KCNQ The gene is as shown in a) or b) below: a) the nucleotide sequence is as shown in SEQ ID No. 1; b) a protein encoding the amino acid sequence shown in SEQ ID No. 2, or a protein encoding a potassium channel activity obtained by substitution, deletion, and / or addition of one or more amino acid residues. This invention has discovered... KCNQ The present invention maintains cell-specific high expression in an ionic environment. KCNQ The gene is homologously conserved in various silk-secreting insects and is specifically expressed in the anterior silk gland. It can be used for the precise identification of anterior silk gland cell types in silk-secreting insects, the molecular improvement of silk fiber properties, and the development of multifunctional silk protein materials, which has important application value.