6 results about "Potassium channel activity" patented technology

The present invention relates to novel compounds, pharmaceutical compositions comprising such compounds and their use for treating, alleviating or preventing diseases or disorders relating to the activity of potassium channels.

The present invention relates to diterpenoid alkaloid compounds in Delphinium aemulans Nevski var. aemulans and a preparation method and use thereof. The compounds use Delphinium aemulans Nevski var. aemulans as a raw material, are extracted with a solvent, treated with acid and base, subjected to solvent extraction, and separated by two, three or four of silica gel column chromatography, Sephadex LH-20 column chromatography, preparative thin layer chromatography or high performance liquid chromatography, and detected and analyzed by thin layer chromatography or high performance liquid chromatography to obtain two new compounds: Compound 1 named aemulanosine A; Compound 2 named aemulanosine B. The voltage-gated potassium channel activities of the two compounds were measured. The experimental results show that aemulanosine A and aemulanosine B isolated from Delphinium aemulans Nevski var. aemulans show inhibitory effects on voltage-gated potassium channel currents and can be used for the preparation of drugs with the activity of inhibiting voltage-gated potassium channel currents.

The present invention relates to novel compounds, pharmaceutical compositions comprising such compounds and their use for treating, alleviating or preventing diseases or disorders relating to the activity of potassium channels.

The present invention relates to a polypeptide which is a temperature-modulated ion channel, wherein said ion channel is a channel comprising four subunits which associate to form a homo- or hetero-tetramer, preferably is a potassium channel, wherein said polypeptide comprises at least one peptide comprising at least one portion of one of said subunits and a portion of the cytoplasmic C-terminal domain of the bacterial voltage-gated sodium channel BacNav, wherein said portion comprises at least one mutation in one of the amino acids in position 267, 271 or 274, wherein said numbering is read with reference to the voltage-gated sodium channel BacNav, SEQ ID NO: 5. The present invention further relates to the use of said polypeptide in the treatment of a condition modulated by potassium channel activity, selected from the group comprising: neuromyotonia, episodic ataxia type 1, hereditary deafness syndromes, benign familial neonatal seizures and periodic hypokalemic paralysis, neuropathic pain, diabetic neuropathic pain, trauma (thoracic surgery), glioblastoma, skin diseases, in particular originating from keratinocyte dysfunctions.

The disclosure provides methods for the treatment of disorders associated with an increase in potassium channel activity using small molecule inhibitors, such as compounds that selectively bind to a Per-Arnt-Sim (PAS) domain of Ether-à-go-go 1 (EAG1) potassium channels. The disclosure also features pharmaceutical compositions comprising therapeutically effective amounts of the disclosed small molecule inhibitors.

This invention discloses a cell marker gene for maintaining the ion environment in silk-secreting insects. KCNQ Identification and application of marker genes for maintaining ion environment in silk-secreting insects KCNQ The gene is as shown in a) or b) below: a) the nucleotide sequence is as shown in SEQ ID No. 1; b) a protein encoding the amino acid sequence shown in SEQ ID No. 2, or a protein encoding a potassium channel activity obtained by substitution, deletion, and / or addition of one or more amino acid residues. This invention has discovered... KCNQ The present invention maintains cell-specific high expression in an ionic environment. KCNQ The gene is homologously conserved in various silk-secreting insects and is specifically expressed in the anterior silk gland. It can be used for the precise identification of anterior silk gland cell types in silk-secreting insects, the molecular improvement of silk fiber properties, and the development of multifunctional silk protein materials, which has important application value.