5 results about "Promoter methylation" patented technology

This invention provides GW2 The application of gene promoter methylation in regulating rice grain width belongs to the field of genetic engineering technology. This invention is based on the discovery of rice... ddm1 Methylation mutation sites in mutants were successfully identified. GW2 A novel epigenetic allelic variant was discovered. GW2 The DNA methylation status of a segment of the upstream promoter region of a gene corresponds to the grain width phenotype in rice. This invention utilizes an epigenetic editing system to demethylate a hypermethylated region in wide-grained rice, resulting in a significantly reduced grain width phenotype. Therefore, by regulating... GW2 GW2 Gene promoter methylation levels can enable precise regulation of rice grain width traits.

This invention belongs to the field of plant genetic engineering technology, specifically involving SsuTDX The application of gene promoter methylation in regulating hemicellulose synthesis. This invention discloses... SsuTDX The application of gene promoter methylation in regulating hemicellulose synthesis, among which SsuTDX The promoter methylation region of the gene has a nucleotide sequence as shown in SEQ ID NO.1. SsuTDX High levels of gene promoter methylation inhibit hemicellulose synthesis; SsuTDX Low methylation levels in the gene promoter promote hemicellulose synthesis. Furthermore, methylation in this region affects SsuMYB295 binding, and temperature can positively regulate methylation levels. This invention provides molecular targets and specific methods for precisely regulating hemicellulose synthesis in *Symplocos edulis*, laying the foundation for targeted breeding of long-fiber varieties, genetic improvement, and material optimization, and has significant practical value.

The invention relates to a reagent for improving the methylation level of a FANCB promoter and application, and particularly provides an epigenetic editing reagent which enables the methylation level of a FANCB promoter region to be increased, so that FANCB is inactivated, and then ovarian cancer is treated and the drug sensitivity of the ovarian cancer is increased.

This invention belongs to the field of biomedical technology, specifically providing the application of TL1A as a biomarker in the diagnosis of cirrhosis. This invention is the first to discover that the TL1A gene promoter exhibits a hypomethylated state in patients with hepatitis B-related cirrhosis, suggesting a close correlation between the methylation level of the TL1A gene promoter and the diagnosis of hepatitis B-related cirrhosis. Therefore, quantitative detection of TL1A gene promoter methylation can indicate the occurrence and progression of hepatitis B-related cirrhosis, thereby assisting in clinical diagnosis and possessing significant practical application value.

In implementations described herein, methylation information is determined with respect to classification regions of a reference genome that are related to the presence of a tumor in a subject. The methylation information can be analyzed using a number of computational techniques to provide metrics related to the presence or absence of a tumor in a given subject, including a determination of tumor fraction.