5 results about "Transplantation procedure" patented technology

There is disclosed a defect sizer tool for selection of an appropriately sized pre-cut core for a cryopreserved osteochondral allograft (COCA) transplantation procedure. In an embodiment, the tool includes an elongated connector that provides a handle portion. A ring measurement guide at one end, with a given diameter, and alignable with a cartilage defect to provide an estimated measurement of a diameter. There is disclosed an instrument kit with a pin, a pin guide, and a reamer configured to slidingly receive the pin, blades at one end, and a rotational drive connector at the other end. In an embodiment, a method for a COCA transplantation procedure includes providing an instrument kit, using the pin guide to place the pin in the subchondral bone, and operating the reamer to score surrounding cartilage prior to the reamer bit portion reaming the subchondral bone to the desired depth. Other embodiments are also disclosed.

This article discloses anti-CD45 antibodies that specifically bind to human CD45, their antigen-binding fragments, and antibody-drug conjugates (ADCs). These antibodies and ADCs can be used in therapeutic applications, including methods that deplete a patient's CD45+ cells. The compositions and methods described herein can be used, for example, to directly treat conditions by depleting CD45+ cancer cells or autologous immune cell populations. The compositions and methods described herein can also be used to prepare patients for hematopoietic stem cell transplantation and to improve the implantation of hematopoietic stem cell grafts by selectively depleting endogenous CD45+ cells prior to the transplantation procedure.

Apparatus and associated methods relate to a pre-transplantation evaluation of human livers using optical coherence tomography. In an illustrative example, a computer-implemented method performed by at least one processor to conduct a non-invasive evaluation of a liver prior to a transplantation procedure. The method includes providing a polarization-sensitive optical coherence tomography (PS-OCT) system. The PS-OCT system may, for example, be coupled to a machine-learning-based system trained to evaluate PC-OCT images of liver. The method may, for example, include determining steatosis, fibrosis, inflammation, and necrosis scores for the liver. The method may, for example, determine whether the liver is unsuitable or suitable for use as a donor liver when the steatosis, fibrosis, inflammation, and necrosis scores fail to meet predetermined donor suitability criteria; and, maintaining the liver under proper preservation conditions when the liver is determined to be suitable for use as a donor liver.

There is disclosed a defect sizer tool for selection of an appropriately sized pre-cut core for a cryopreserved osteochondral allograft (COCA) transplantation procedure. In an embodiment, the tool includes an elongated connector that provides a handle portion. A ring measurement guide at one end, with a given diameter, and alignable with a cartilage defect to provide an estimated measurement of a diameter. There is disclosed an instrument kit with a pin, a pin guide, and a reamer configured to slidingly receive the pin, blades at one end, and a rotational drive connector at the other end. In an embodiment, a method for a COCA transplantation procedure includes providing an instrument kit, using the pin guide to place the pin in the subchondral bone, and operating the reamer to score surrounding cartilage prior to the reamer bit portion reaming the subchondral bone to the desired depth. Other embodiments are also disclosed.

This invention provides compositions and methods useful for treating CD45+ cell depletion, and in particular for treating various hematopoietic disorders, metabolic disorders, cancer, and autoimmune diseases. [Solution] The compositions and methods described herein can be used, for example, to treat a disorder by depleting a population of CD45+ cancer cells or autoimmune cells. The compositions and methods described herein can also be used to prepare a patient for allogeneic hematopoietic stem cell transplantation therapy and to improve the engraftment of allogeneic hematopoietic stem cell transplants by selectively depleting endogenous hematopoietic stem cells before the transplantation procedure.