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Titanium net with fimbrin and its prepn and application

A technology of silk fibroin and titanium mesh, applied in biochemical equipment and methods, medical science, microbiology, etc., to reduce complications, promote tracheal mucosal repair and clinical reconstruction of tracheal defects

Inactive Publication Date: 2008-02-13
AFFILIATED HUSN HOSPITAL OF FUDAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there is no report on the application of silk fibroin in the reconstruction of tracheal defects at home and abroad.

Method used

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  • Titanium net with fimbrin and its prepn and application
  • Titanium net with fimbrin and its prepn and application
  • Titanium net with fimbrin and its prepn and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Embodiment 1 prepares silk fibroin

[0064] Using waste mulberry silkworm raw silk in NaHCO at 100 °C 3 (0.5wt%) degumming in an aqueous solution for 45 minutes, and dissolving the degummed silk in 9.3mol / L LiBr aqueous solution, stirring continuously at 45°C for about 2 hours until the silk is completely dissolved. Filter with eight layers of medical gauze to remove undissolved silk and impurities. The obtained silk fibroin protein salt solution is dialyzed with deionized water for four days to remove LiBr in the solution. The cut-off molecular weight of the dialysis bag is 12,000-14,000Da. The prepared silk fibroin has a concentration of about 4%, further concentrating it, continuing to dialyze with 10% PEG for one day, centrifuging the dialyzed silk fibroin solution at 6000 rpm for 15 minutes to remove impurities, and leaving the supernatant. The obtained silk fibroin has a concentration of 20%, and it is stored in a refrigerator at 4° C. as a storage solution for f...

Embodiment 2

[0065] Example 2 Preparation of silk fibroin coated titanium mesh

[0066] Use medical titanium mesh (commercially available) to make the shape of a trachea-like ring-like structure with the same curvature and thickness as the experimental animal rabbit trachea. After ethylene oxide fumigation and sterilization, the titanium mesh is repeatedly dipped in The above-mentioned silk fibroin solution with a dilution concentration of 6% stored at low temperature is taken out and placed in an oven to dry at 60 degrees. Repeat this 6-10 times to make the surface evenly coated with silk fibroin material and keep the pores of the titanium mesh unsealed. All of the above processes were performed aseptically.

Embodiment 3

[0068] Use medical titanium mesh (commercially available) to make the shape of a trachea-like ring-like structure with the same curvature and thickness as the experimental animal rabbit trachea. After ethylene oxide fumigation and sterilization, the titanium mesh is repeatedly dipped in The above-mentioned silk fibroin solution with a dilution concentration of 12% stored at low temperature is taken out and placed in an oven to dry at 60 degrees. Repeat this 6-8 times to make the surface evenly coated with silk fibroin material and keep the pores of the titanium mesh unsealed. All of the above processes were performed aseptically.

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Abstract

The present invention belongs to the field of tissue engineering and medical material technology, and is especially titanium net with fimbrin coating and its preparation process and application in reconstructing trachea default. The present invention prepares fimbrin-titanium net complex with medical titanium net as support material and fimbrin to form coating. Fimbrin has excellent biocompatibility and can promote the growth of fibroblast and mucosa cell, speed healing, reduce complications. Clinically, the present invention is used in repairing trachea default. The present invention is significant in the research of fimbrin in promoting repair of trachea mucosa, reconstructing trachea default and reducing complications during reconstructing trachea default.

Description

technical field [0001] The invention belongs to the field of tissue engineering and medical materials, and in particular relates to a silk fibroin-coated titanium mesh, a preparation method thereof and an application in tracheal defect reconstruction. Background technique [0002] At present, when the body has extensive damage to the trachea due to inflammation, trauma, tumors or other lesions, and a long segment of the trachea is removed, the defective trachea needs to be repaired. For a long time, the problem of repairing tracheal cartilage defects has puzzled clinicians. One-stage end-to-end anastomosis is only suitable for the repair of local defects. When the length of the defect exceeds 6.0 cm, serious complications such as anastomotic leakage are likely to occur due to high anastomotic tension. The rapid development of tissue engineering technology research has brought new hope to tracheal reconstruction, but since the initial attempt in 1994, there has been no break...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/00A61F2/04C12N5/06
Inventor 赵霞倪玉苏周梁严文洪邵正中陈新曹正兵
Owner AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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