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Therapeutic vaccine composition for hepatitis B

A technology of hepatitis B vaccine and composition, which can be used in drug combinations, antibody medical components, digestive system, etc., and can solve problems such as inability to clear HBV

Inactive Publication Date: 2008-06-04
张宜俊 +3
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Problems solved by technology

And the development of nucleoside analogs has made great progress in recent years, but these drugs can only inhibit the replication of HBV, and cannot completely eliminate HBV in the human body.

Method used

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Embodiment

[0027] In the embodiment of the present invention, the HBsAg vaccine is provided by Dalian Hanxin Biological Products Co., Ltd., and the PA-MSHA vaccine is provided by Hainan Weixi Biopharmaceutical Co., Ltd.

[0028] rhIL-12 was developed by the inventors of the present invention. Since IL-12 is a heterodimeric protein composed of two subunits, P40 and P35, through multiple pairs of disulfide bonds, the genes encoding P35 and P40 subunits are located in different on the chromosome. The P35 subunit cannot be secreted into the extracellular space alone, but the P40 subunit can be secreted into the extracellular space alone. Therefore, the key to the expression of biologically active IL-12 is the balanced expression of the two subunits in the same cell. Therefore, the constructed CHO cell line must allow the balanced expression of the two subunits of IL-12. To this end, we inserted P40cDNA and P35cDNA into two vectors with different expression efficiencies, and then co-transfec...

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Abstract

The invention relates to a vaccine composite used to treat hepatitis-B, wherein it contains 10-20 mug recombined HBsAg protein vaccine, 10-20 mug recombined interleukins 12, and 0.9-1.8 million bacillus pyocyaneus, and the left is water in each unit ml. The inventive composite can activate several immunity targets as NKT, cell, NK cell, etc, to break HBV immunity resistance, rebuild cell immunity function, and restrain HBV.

Description

technical field [0001] The invention relates to a biological preparation, in particular to a therapeutic hepatitis B vaccine composition for treating chronic hepatitis B. technical background [0002] Chronic hepatitis B is one of the common infectious diseases in my country. my country is a high prevalence area of ​​hepatitis B virus (HBV). HBV infection is a serious public health problem. In 2004, the Chinese Center for Disease Control and Prevention conducted the blood sample detection results of the 2002 Nutrition and Health Survey of Chinese Residents, which showed that the prevalence rate of HBsAg in the general population in my country was as high as 9.09%. Based on this, it is speculated that there are about 120 million chronic HBV infected people in my country People, of which about 30 million cases of chronic hepatitis B. Chronic hepatitis B has brought a heavy economic burden to the country and individuals. The direct and indirect loss of chronic hepatitis B in my...

Claims

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Application Information

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IPC IPC(8): A61K39/295A61K39/29A61P1/16A61P31/20
Inventor 张宜俊邱向南夏书奇杨联勇曾振飞叶倩君赵峰王添章曾水娣郭凯璇王翠玲
Owner 张宜俊
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