Synthesis method of mesoporous medication treatment system for treating hepatitis B

A synthesis method and mesoporous technology, which can be applied in the fields of drug combination, drug delivery, and pharmaceutical formulation, can solve the problems of immune dysfunction, the incidence of advanced liver disease has not been significantly reduced, and achieve the effect of promoting liver cell regeneration.

Inactive Publication Date: 2020-07-28
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Chronic viral hepatitis has become a public health problem of worldwide concern. Although the implementation of hepatitis B vaccine is effective in reducing the incidence of hepatitis B, the incidence of advanced liver disease has not yet been significantly reduced. The basic research on the mechanism is gradually deepening, and it is found that the host-specific antiviral immune tolerance and immune dysfunction may be the most important reasons

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] The synthesis method of the mesoporous drug treatment system for hepatitis B treatment of the present invention, the steps are as follows:

[0012] 1) Preparation of copper sulfide template

[0013] (1) 49mL of cetyltrimethylammonium bromide aqueous solution is added in the three-necked flask of 100mL;

[0014] (2) Stir in a water bath at 35°C at constant temperature, and add sodium sulfide (100mM, 0.5mL) aqueous solution after 10 minutes;

[0015] (3) After 10 minutes, copper chloride (100mM, 0.5mL) aqueous solution was added, and the solution immediately changed from colorless to brown;

[0016] (4) Raise the temperature of the water bath to 90°C, and keep at a constant temperature of 90°C for 1 hour;

[0017] (5) Centrifugal recovery copper sulfide template;

[0018] 2) Synthesis of PEG-modified mesoporous silica by hydrothermal method

[0019] (1) Add 100mg of copper sulfide template to deionized water, and heat the water bath to 70°C;

[0020] (2) Add structur...

Embodiment 2

[0032] The synthesis method of the mesoporous drug treatment system for hepatitis B treatment of the present invention, the steps are as follows:

[0033] 1) Preparation of copper sulfide template

[0034] (1) 49mL of cetyltrimethylammonium bromide aqueous solution is added in the three-necked flask of 100mL;

[0035] (2) Stir in a water bath at 35°C at constant temperature, and add sodium sulfide (100mM, 0.5mL) aqueous solution after 10 minutes;

[0036] (3) After 10 minutes, copper chloride (100mM, 0.5mL) aqueous solution was added, and the solution immediately changed from colorless to brown;

[0037] (4) Raise the temperature of the water bath to 90°C, and keep at a constant temperature of 90°C for 1 hour;

[0038] (5) Centrifugal recovery copper sulfide template;

[0039] 2) Synthesis of PEG-modified mesoporous silica by hydrothermal method

[0040] (1) Add 100mg of copper sulfide template to deionized water, and heat the water bath to 70°C;

[0041] (2) Add structur...

Embodiment 3

[0053] The synthesis method of the mesoporous drug treatment system for hepatitis B treatment of the present invention, the steps are as follows:

[0054] 1) Prepare copper sulfide template;

[0055] (1) 49mL of cetyltrimethylammonium bromide aqueous solution is added in the three-necked flask of 100mL;

[0056] (2) Stir in a water bath at 35°C at constant temperature, and add sodium sulfide (100mM, 0.5mL) aqueous solution after 10 minutes;

[0057] (3) After 10 minutes, copper chloride (100mM, 0.5mL) aqueous solution was added, and the solution immediately changed from colorless to brown;

[0058] (4) Raise the temperature of the water bath to 90°C, and keep at a constant temperature of 90°C for 1 hour;

[0059] (5) Centrifugal recovery copper sulfide template;

[0060] 2) Synthesis of PEG-modified mesoporous silica by hydrothermal method

[0061] (1) Add 100mg of copper sulfide template to deionized water, and heat the water bath to 70°C;

[0062] (2) Add structure-dire...

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Abstract

The invention relates to a synthesis method of a mesoporous medication treatment system for treating hepatitis B. The synthesis method comprises main steps of (1) preparing a copper sulfide formwork;(2) performing synthesis to obtain PEG modified mesoporous silica by a hydrothermal method; and (3) loading thymosin alpha 1 and hepatocyte growth-promoting factors. The PEG modified mesoporous silicahas the effects of slow control of medicine release and targetting livers through the clearing effect of the liver, and the thymosin alpha 1 has dual immunomodulation effects, can reconstruct immunologic functions of patients with primary immunodeficiency and secondary immunodeficiency, and can cause immune response. The hepatocyte growth-promoting factors can promote regeneration of liver cells,and have protection effects on damage of liver cells.

Description

technical field [0001] The invention relates to the field of preparation of a mesoporous drug treatment system, in particular to a method for synthesizing a mesoporous drug treatment system for treating hepatitis B. Background technique [0002] Chronic viral hepatitis has become a public health problem of widespread concern worldwide. Although the implementation of hepatitis B vaccine is effective in reducing the incidence of hepatitis B, the incidence of advanced liver disease has not yet been significantly reduced. Mechanism research has gradually deepened, and it has been found that host-specific antiviral immune tolerance and immune dysfunction may be the most important reasons. [0003] Thymosin is a group of physiologically active polypeptides secreted by thymus tissue. It has the function of regulating and enhancing the immune function of human cells. It can promote the maturation of T lymphocytes in the peripheral blood after mitogen activation, and has the function...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/69A61K47/60A61K38/22A61P31/20A61P1/16
CPCA61K47/6923A61K47/6935A61K47/60A61K38/2292A61K38/1833A61P31/20A61P1/16A61K2300/00
Inventor 郑斌王树超明东甘霖
Owner TIANJIN UNIV
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