Application of timosaponin for treating anxiety disorders

A technology of timosaponin and anxiety disorder, applied in the field of timosaponin for the treatment of anxiety disorder

Inactive Publication Date: 2007-07-25
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional Chinese medicine often takes drugs such as calming the nerves, soothing the liver, nourishing yin, and clearing heat. Anemarrhena has the effect of clearing away heat and nourishing yin. It is used to treat anxiety of yin deficiency and internal heat, which is in line with the principle of dialectical medicine in traditional Chinese medicine. However, Anemarrhena or Anemarrhena extracts The active ingredient timosaponin in the treatment of anxiety has not been reported

Method used

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Embodiment Construction

[0004] Choose the Anemarrhena plucked in spring or autumn, remove its fibrous roots, wash, dry, and slice, and then prepare the active substance of Anemarrhena by conventional methods, such as the ethanol infusion method, that is, timosaponin, the timosaponin For the preparation of medicines for treating anxiety disorders. And the test on the anxiolytic effect of yin-deficiency mice has fully proved the anxiolytic effect of timosaponin, which can be effectively used to prepare drugs for treating anxiety. The extraction method of anemarrhena extract timosaponin is: add 8 times the amount of 80% ethanol to the anemarrhena decoction pieces and reflux extraction three times, each time for 2 hours, filter through gauze, combine the filtrate, recover the ethanol from the filtrate until it has no alcohol smell, add appropriate amount of petroleum ether to degrease Extract three times, discard the petroleum ether layer, take the lower water layer, extract the water layer three times w...

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Abstract

An application of the timosaponin extracted from anemarrhena rhizome in preparing the medicine for treating dysphoria is disclosed. The preparing process of timosaponin is also disclosed.

Description

1. Technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to the application of timosaponin in treating anxiety. 2. Background technology [0002] Anemarrhena is the rhizome of Liliaceae Anemarrhena, which grows on the sunny slopes of mountains and Lianggang areas. It is produced in Northeast China, Shanxi, Shaanxi, Henan, Hebei, Inner Mongolia and other places. Its nature and taste are bitter, sweet, and cold. Lung and kidney meridians, clearing away heat and restlessness, moistening dryness and nourishing yin. Traditional medicine believes that it is mainly used to treat strong heat and polydipsia, coma and delirium, lung heat cough, bone steaming night sweats and thirsty drinking. The active substance Zhimu extracted from Zhimu Saponins further enhance the traditional medicinal value of Anemarrhena. Anxiety disorder is the name of disease in Western medicine. The disease is a neurological disorder characterized by widespr...

Claims

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Application Information

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IPC IPC(8): A61K36/8964A61P25/22
Inventor 崔瑛代永霞冯静
Owner HENAN UNIV OF CHINESE MEDICINE
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