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Traditional Chinese medicinal composition containing red sage root and kudzuvine root and its preparation

A technology of composition and traditional Chinese medicine, which is applied in the field of pharmaceutical composition and preparations for treating cardiovascular diseases, and can solve problems such as difficult preparation of dripping pills

Active Publication Date: 2011-09-21
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the strict requirements of the drop pill preparation process on the matrix excipients, it is often difficult to prepare drop pills that meet the quality requirements after replacing the matrix excipients. Therefore, finding a suitable matrix excipient to replace the current polyethylene glycol has become a constant effort of medical personnel. direction

Method used

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  • Traditional Chinese medicinal composition containing red sage root and kudzuvine root and its preparation
  • Traditional Chinese medicinal composition containing red sage root and kudzuvine root and its preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] The raw materials are 375g of Danshen, 118g of Pueraria lobata, 4.5g of balsamic oil, and 80g of ginseng

[0067] Salvia miltiorrhiza, kudzu root and ginseng were decocted in 5 times the amount of water, decocted for 2 hours, filtered, and the filter residue was extracted for the second time, added 4 times the amount of water, decocted for 1 hour, filtered, the filter residue was discarded, and the filtrate was combined. The filtrate is concentrated under reduced pressure to a ratio of 1: 0.9 to 1.1 between the volume of the medicinal solution (L) and the weight (Kg) of the medicinal material, adding ethanol to make the alcohol concentration of the medicinal solution at 70%, leaving it to stand, filtering, and concentrating the filtrate to obtain a relative density of 1.32 ~1.40 (55°C) extract. Add balsamic oil, dry, make granules, compress into tablets, or coat with sugar, that is to say.

Embodiment 2

[0069] Danshen 465g, Pueraria 30g.

[0070] Salvia miltiorrhiza and kudzu root are extracted with 70% ethanol, and the extract is micro-filtered with a ceramic membrane to collect the filtrate; The pressure is 0.20kPa lower than the inlet pressure. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; in the process of ultrafiltration, periodic pressure fluctuations are adopted, and the pressure fluctuation difference is 0.2Mpa. The flow rate of the feed liquid is 3.0m / s. During the ultrafiltration process, periodic flow fluctuations are used to generate pulsating or unstable flows in the membrane channel. The difference in flow rate fluctuations is 2.0m / s. Nitrogen is intermittently fed into the ultrafiltration system , to form a gas-liquid pulse flow, and the period is 2h to ventilate once, each time for 1 minute. The temperature of the feed liquid is 40°C. When the original feed liquid is concentrated by 1 / 8, add ...

Embodiment 3

[0073] The raw materials are 485g of salvia miltiorrhiza, 30g of kudzu root, 100g of angelica, and 2.2g of borneol.

[0074] Add 5 times the amount of water to Danshen, Pueraria and Angelica, decoct for 2 hours, filter, and extract the filter residue for the second time, add 4 times the amount of water, fry for 1 hour, filter, discard the filter residue, and combine the filtrate. The filtrate is concentrated under reduced pressure to a ratio of 1: 0.9 to 1.1 between the volume of the medicinal solution (L) and the weight (Kg) of the medicinal material, adding ethanol to make the alcohol concentration of the medicinal solution at 70%, leaving it to stand, filtering, and concentrating the filtrate to obtain a relative density of 1.32 ~1.40 (55°C) extract. The extract and borneol are fluidized with lactose in a batch fluidized bed, dried, and made into granules.

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Abstract

The present invention discloses a Chinese medicinal composition for treating cardiovascular diseases, which is prepared mainly from root of red rooted saliva, kudzuvine root, Chinese angelica root, motherwort, astragalus root, ginseng or Codonopsis pilosula, any one of the compositions may also comprise baras camphor, rosewood oil, liquidambar orientalis mill, musk or musk ketone. The present invention also discloses preparations using any one of the medicinal compositions as the effective constituents, preferably drop pills. The auxiliary materials of the drop pill substrate can be polyethylene glycol or natural materials, especially those of plant sources. The medicament has quick effect and good therapeutic action for coronary disease and angina pectoris.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating cardiovascular disease and a preparation thereof, in particular to a pharmaceutical composition for treating cardiovascular disease which is prepared from traditional Chinese medicinal materials. Background technique [0002] According to an epidemiological survey in my country, the morbidity and mortality of cardiovascular and cerebrovascular diseases have been on the rise in the past 50 years, whether in rural or urban areas. In the 1950s and 1960s, cardiovascular disease and cerebrovascular disease ranked fifth and sixth among the causes of death in my country, respectively, and after 1970, they rose to the second and third respectively, and deaths from cardiovascular and cerebrovascular diseases have accounted for the first cause of death from all diseases. The proportion of deaths due to cardiovascular and cerebrovascular diseases in the total number of deaths in my country has inc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61K9/20A61K47/36A61P9/10A61K35/55A61K31/122
Inventor 李旭郑永锋白雨
Owner TIANJIN TASLY PHARMA CO LTD
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