Reagent kit detecting pulmonary cancer susceptibility through CYP2E1 gene

Abstract

The present invention discloses a reagent kit to detect lung cancer susceptibility, which comprises a specificity tracer and a specificity fluorescence probe to detect No. 176 SNP locus of gene SEQ ID No: 1 of CYP2E1 and a normal assembly for quantitative fluorescence PCR detection. The reagent kit of the present invention forecasts individual lung cancer susceptibility by analyzing individual carrying type of SNP locus gene of on CYP2E1 gene.

Description

technical field

[0001] The present invention relates to a kit for detecting disease susceptibility, especially a kit for detecting susceptibility to lung cancer, by detecting the single nucleotide of cytochrome P4502E1 enzyme (cytochrome P450, family2, subfamily E, polypeptide1, CYP2E1) polymorphism (SNP) loci to predict individual susceptibility to lung cancer. Background technique

[0002] Primary bronchial lung cancer, referred to as lung cancer, is one of the most common malignant tumors in the world and a serious threat to human health and life. Tumor cells originate from the bronchial mucosa or glands, and often have regional lymph node and hematogenous metastasis. In the early stage, respiratory symptoms such as irritating cough and blood in the sputum are often present. The speed of disease progression is related to the biological characteristics of the cells.

[0003] For half a century, the morbidity and mortality of lung cancer in all countries in the world have ...