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Novel multiple organs storage protection liquid

A multi-organ and protective solution technology, applied in the preservation, application, and animal husbandry of human or animal bodies, can solve the problems of high price, high viscosity, weak antioxidant effect, etc., achieve low price and increase perfusion time , The effect of viscosity bottom

Inactive Publication Date: 2008-06-18
谭敦宪
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AI Technical Summary

Problems solved by technology

The main disadvantage of UW liquid is its high viscosity, weak anti-oxidation effect and high price

Method used

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  • Novel multiple organs storage protection liquid
  • Novel multiple organs storage protection liquid
  • Novel multiple organs storage protection liquid

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Experimental program
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Effect test

Embodiment approach

[0012] 1. Materials and methods

[0013] 1. Chemical reagents Most of the chemical reagents were purchased from Sigma Chemicals (Sigma Chemicals, St.Louis, MO, USA), and were of high performance liquid phase (HPLC) grade. One-liter UW solution was purchased from the University of Wisconsin (University of Wisconsin), and the origin of each analysis kit can be found in the main text. The novel multi-organ storage protection liquid of the present invention is prepared according to the formula in Table 2. Both organ storage and protection solutions were stored in a 4°C refrigerator for later use.

[0014] 2. Animals Male SD rats, weighing 250-300 grams, were purchased from Guangdong Medical Experimental Animal Center. Divided into normal control group (group 1, 8 rats), phosphate buffer control group (group 2, 8 rats), new multi-organ storage protection solution experimental group (group 3, 8 rats) and UW solution experimental group (Group 4, 8 rats).

[0015] 3. Organ collect...

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PUM

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Abstract

The invention is a novel multi-organ storage protective solute, which belongs to the organ transplantation section in the biomedicine technique field. The organ transplantation has the critical step of organ storage which decides the success or failure of transplantation. The phenomena of ischemia and reperfusion during organ storage lead to mass generation of free radicals which cause the oxidative damage to the stored organ. The invention creatively applies an anti-oxidation system composed of melatonin, vitamin C and water miscible vitamin E for reducing the oxidative damage caused by free radical generation during organ storage; mannitol is used to maintain the solution osmotic pressure and reduce the solution viscosity; and light concentration glucose is used for meeting the lowest metabolism requirements of the organ. The experiment shows that the multi-organ storage effects of the invention are superior over the organ storage solution (UW liquid) widely applied worldwide and nationwide currently. The invention is used for storing the off-body kidney, liver, pancreas, heart and lung before transplantation, thereby extending the effective storage time, increasing the transplantation success rate and offering chances of organ transplantation for more patients.

Description

Technical field: [0001] The invention is a novel multi-organ storage protection solution in the field of biomedical organ transplantation. Background technique: [0002] Organ transplantation is the ultimate treatment for certain diseases. Through organ transplantation, tens of thousands of patients around the world can continue their lives every year. A very critical step in organ transplantation is the storage and protection of isolated organs, which largely determines the success or failure of organ transplantation. In principle, organ transplantation requires the transplantation of a living organ. However, organs cut from other donors with no blood supply (most of the donors are deceased) cannot be transplanted into the patient immediately, there must be a storage and transfer process, and at a normal temperature of 35-37 ℃ Under these circumstances, the cells of the storage organ still undergo hypoxic metabolism, causing intracellular acidosis, mitochondrial energy im...

Claims

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Application Information

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IPC IPC(8): A01N1/02
Inventor 谭敦宪
Owner 谭敦宪
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