Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of gambogic acid polylactic acid and gambogic acid, which is applied in the field of medicine, can solve problems such as poor stability and easy degradation, and achieve the effects of increasing stability, improving bioavailability, and good solubilization
Inactive Publication Date: 2008-07-30
NORTHWEST A & F UNIV
View PDF0 Cites 7 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
However, gambogic acid injections have poor stability and are prone to degradation. Therefore, finding new carrier materials, improving the solubility and stability of gambogic acid and improving the effect of drugs are the primary problems to be solved for the improvement of gambogic acid dosage forms
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0049] 1) Weigh 20 mg of gambogic acid and 75 mg of polylactic acid, dissolve them in 20 mL of acetonitrile, and make an organic phase;
[0050] 2) Weigh a certain amount of Poloxamer F-68 0.2g and dissolve it in 20mL water to make the water phase;
[0051] 3) Add the organic phase to the water phase drop by drop, and magnetically stir for 4 hours; distill under reduced pressure to remove the organic solvent and a part of the water; filter with a 0.22 μm microporous membrane to obtain milky yellow gambogic acid polylactic acid nanoparticle solution . The measured average particle diameter was 52.6 nm.
Embodiment 2
[0053] 1) Accurately weigh 20 mg of gambogic acid and 50 mg of polylactic acid, and dissolve them in 20 mL of acetone.
[0054] 2) Weigh 0.4g of Poloxamer F-68 and dissolve it in 40mL of water.
[0055] 3) The method is the same as in Example 1.3) to obtain milky yellow gambogic acid polylactic acid nanoparticles. The average particle diameter was measured to be 51.2 nm. Ultra-fast refrigerated centrifugation (4°C, 50 000r·min-1) for 1.5h. Gambogic acid polylactic acid nanoparticle powder was obtained.
Embodiment 3
[0057] 1) Accurately weigh 20 mg of gambogic acid and 75 mg of polylactic acid, and dissolve them in 20 mL of acetone.
[0058] 2) Weigh 0.2 g of poloxamer F-68 and dissolve it in 40 mL of aqueous ethanol (ethanol: water = 1:1).
[0059] 3) The method is the same as in Example 1.3) to obtain milky yellow gambogic acid polylactic acid nanoparticles. The average particle diameter was measured to be 50.6 nm.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Property
Measurement
Unit
particle diameter
aaaaa
aaaaa
diameter
aaaaa
aaaaa
particle size
aaaaa
aaaaa
Login to view more
Abstract
The invention discloses a gamboges acid nanometer particle preparation and is prepared by the components of raw material gamboges acid 0.05 to 1.5 percent, polylactic acid 0.05 to 1.5 percent, surfactant 0.1 to 1.5 percent, organic solvent 33 to 50 percent and the allowance of water with the following steps: dissolving the polylactic acid into the organic solvent and dispersing the gamboges acid in the mixed solution of the polylactic acid and the organic solvent; the preparation is obtained by adding the mixed solution with the gamboges acid into water phase with the surfactant, stirring magnetically for 4 hours, vacuum distillation and filtering with a 0.22Mum micro-porous filtering film after the organic solvent and part of water are distillated. The drug with a clear system, the particle size between 10 to 100nm and good dispersion and stability can significantly solubilize drugs, has a targeting effect for reticuloendothelial cells and concentrate at lesion sites, thus improving the curing effect of the drug and reduces the side effect of the drug. Additionally, the drug has a slowly releasing effect, can maintain constant plasma concentration or pharmacologic effect for a long time and improve drug bioavailability.
Description
technical field [0001] The invention belongs to the field of medicine, and relates to a new dosage form of gambogic acid extracted from traditional Chinese medicine with antitumor effect, in particular to a nanoscale preparation of gambogic acid and a preparation method thereof. Background technique [0002] Gambogic acid (Gambogic acid, GA) is a dry resin secreted by Garcinia cambogia. Mainly produced in India, Cambodia, Thailand and Vietnam. The solubility in water is poor, but it is easily soluble in organic solvents such as ethanol, methanol, acetone, ethyl acetate, and acetonitrile. [0003] Gambogic acid has the functions of detumescence, detoxification, hemostasis, insecticide, etc. Its main pharmacological effects are: ①Anti-tumor effect, gamboge has effect on ECA, ARS, S 180 , S 37 , MA 737 , U 4 ,ARA 4 , W 256 The inhibition rate is 35% to 38%, and it has different degrees of inhibition or killing effects on the human cancer cell lin...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more