Isomorellic acid polylactic acid nano particle preparation and preparing method thereof

Abstract

The invention discloses a gamboges acid nanometer particle preparation and is prepared by the components of raw material gamboges acid 0.05 to 1.5 percent, polylactic acid 0.05 to 1.5 percent, surfactant 0.1 to 1.5 percent, organic solvent 33 to 50 percent and the allowance of water with the following steps: dissolving the polylactic acid into the organic solvent and dispersing the gamboges acid in the mixed solution of the polylactic acid and the organic solvent; the preparation is obtained by adding the mixed solution with the gamboges acid into water phase with the surfactant, stirring magnetically for 4 hours, vacuum distillation and filtering with a 0.22Mum micro-porous filtering film after the organic solvent and part of water are distillated. The drug with a clear system, the particle size between 10 to 100nm and good dispersion and stability can significantly solubilize drugs, has a targeting effect for reticuloendothelial cells and concentrate at lesion sites, thus improving the curing effect of the drug and reduces the side effect of the drug. Additionally, the drug has a slowly releasing effect, can maintain constant plasma concentration or pharmacologic effect for a long time and improve drug bioavailability.

Description

technical field

[0001] The invention belongs to the field of medicine, and relates to a new dosage form of gambogic acid extracted from traditional Chinese medicine with antitumor effect, in particular to a nanoscale preparation of gambogic acid and a preparation method thereof. Background technique

[0002] Gambogic acid (Gambogic acid, GA) is a dry resin secreted by Garcinia cambogia. Mainly produced in India, Cambodia, Thailand and Vietnam. The solubility in water is poor, but it is easily soluble in organic solvents such as ethanol, methanol, acetone, ethyl acetate, and acetonitrile.

[0003] Gambogic acid has the functions of detumescence, detoxification, hemostasis, insecticide, etc. Its main pharmacological effects are: ①Anti-tumor effect, gamboge has effect on ECA, ARS, S 180 , S 37 , MA 737 , U 4 ,ARA 4 , W 256 The inhibition rate is 35% to 38%, and it has different degrees of inhibition or killing effects on the human cancer cell lin...

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