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Prophylactic/ameliorating agent for menopausal disorder and functional beverage/food

A technology of barriers and active intermediates, applied in the field of menopausal barriers prevention and improvement agents and functional food and beverages, can solve the problems of inability to obtain the effect, active ingredients do not undergo metabolism and activation, and achieve the effect of safe oral intake

Inactive Publication Date: 2008-08-27
CALPIS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

That is, in many cases, when a human ingests a crude drug, the active ingredient contained in the crude drug is metabolized and activated by intestinal bacteria to exhibit an effect, but there are also cases where the active ingredient Metabolism and activation are not carried out, and the effect cannot be obtained even if ingested

Method used

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  • Prophylactic/ameliorating agent for menopausal disorder and functional beverage/food

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1. Lignan metabolism function of Lactobacillus acidophilus

[0050] Evaluation of lignan metabolic functions of various microorganisms. Use MRS medium or GAM medium to pre-culture various microorganisms shown in the following Tables 1-3 at 37° C. for 20-24 hours, and plant bacteria in 10 ml of MRS medium or GAM medium with 1-3%. Eucommia lignans (pinoresinol or eucommia resinol) were added until the final concentration in the medium was 0.5 mM, and culture was continued at 37°C. Sampling was performed over time, and the metabolic conversion of added lignans to secoisolaricoresinol was quantitatively measured by HPLC. A sample in which 50% or more of lignan was converted is indicated by ◯, and a sample in which almost no conversion was performed is indicated by ×. The results are shown in Tables 1-3.

[0051] [Table 1]

[0052] Table 1

[0053] pinoresinol → secoisolaricine resinol

[0054] [Table 2]

[0055] pinoresinol → secoisolar...

Embodiment 2

[0059] Example 2. Binding of lignans and their metabolites to estrogen receptors

[0060] In 10 mM Tris Buffer (Tris Buffer) (containing 0.1% BSA, 10% glycerol, 1 mMDTT) of pH 7.4 containing recombinantly expressed human estrogen receptor α or β, make 1 mM sample (pinoresinol·diglucoside, pinoresinol, secoisolaricine resinol) and 0.5 nM tritium-leveled estradiol were reacted at 25 degrees for 2 hours. After completion of the reaction, the acceptor was recovered and washed, and the amount of tritium-leveled estradiol bound to the acceptor was measured according to a usual method. at 0.5nM[ 3 H] The amount of estradiol binding to the receptor is 100%, and the [ 3 H] The binding degree of estradiol was obtained by subtracting the binding degree from 100 as the binding inhibition rate. The results are shown in the table below.

[0061] [Table 4]

[0062] Table 4

[0063] Binding Inhibition Rate of Binding to Estrogen Receptor α

[0064] Inhibition rate(%)

[...

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PUM

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Abstract

Disclosed is a method for producing an estrogen-like active intermediate (e.g., secoisolariciresinol) by culturing a lignan (e.g., a lignan derived from Gymnema sylvestre) together with a bacterium Lactobacillus acidophilus. Also disclosed a prophylactic / ameliorating agent for menopausal disorder and a functional beverage / food for preventing / ameliorating menopausal disorder comprising a lignan cultured together with a bacterium Lactobacillus acidophilus as an active ingredient.

Description

technical field [0001] The present invention relates to a menopausal disorder preventing / improving agent and a functional food and drink for obtaining the effect of preventing and improving various symptoms accompanying the onset of menopause. Background technique [0002] Menopausal disorder is a self-reported symptom of variable physical and mental symptoms caused by a decrease in the secretion of estrogen (estrogen) from the ovaries before and after menopause. Then, as we grow older, various symptoms such as skin aging, hyperlipidemia, osteoporosis, and decreased brain function begin to appear. [0003] Hormone replacement therapy (HRT), which administers estrogen, is known to be effective against the above symptoms. However, in July 2002, WHI (Women's Health Initiative) announced the interim results of 5 years of use, and reported risks such as an increase in the incidence of breast cancer due to estrogen administration. As a result, there is now a demand for safer men...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P7/22A23L1/30A61K31/085A61K35/74A61P15/12A23L33/10A23L33/135A61K31/065A61K31/09A61K31/341A61K35/747A61P5/30C12N1/20C12R1/23
CPCA23L2/52A61K31/085A61K35/747A61K36/27A23L33/10A23L33/135A61P5/30A61P15/12C07D307/12C07D307/33C07D493/04C12P7/22A61K2300/00
Inventor 服部征雄中村宪夫吉村千秋增山明弘高野俊明
Owner CALPIS
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