Preparation of pharmaceutical combination enteric soft capsules containing eucalyptol, limonene and a-pinene

A technology of enteric-coated soft capsules and limonene, which is applied in drug combinations, medical preparations containing active ingredients, capsule delivery, etc., to achieve the effects of good adhesion, wide sources, smoothness and toughness

Inactive Publication Date: 2008-09-03
BEIJING GRAND JOHAUM PHARMA CO LTD
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Problems solved by technology

According to the latest investigation, it is known that this preparation method has not been applied in the production of enteric-coated soft capsules of this pharmaceutical composition at home and abroad at present.

Method used

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  • Preparation of pharmaceutical combination enteric soft capsules containing eucalyptol, limonene and a-pinene
  • Preparation of pharmaceutical combination enteric soft capsules containing eucalyptol, limonene and a-pinene
  • Preparation of pharmaceutical combination enteric soft capsules containing eucalyptol, limonene and a-pinene

Examples

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Embodiment 4

[0039] Example 4 Long-term stability investigation of enteric-coated soft capsules containing eucalyptol, limonene and α-pinene The pharmaceutical composition obtained in Examples 1-3 containing eucalyptol, limonene and α-pinene enteric Soft capsules, under the experimental conditions of temperature below 20°C and relative humidity of 60%±15%, placed for 0 months, 3 months, 6 months, 9 months, 12 months, 18 months, 24 36 months and 36 months, samples were taken for detection, and the following indicators were investigated, and the inspection results were compared with 0 months to observe its stability. The inspection results are shown in Table 3-5.

[0040] Stability inspection traits, disintegration time limit, related substances, content and other indicators, the test method refers to the method under the corresponding item in the second appendix of the "Pharmacopoeia of the People's Republic of China" 2005 edition. The indicators required are:

[0041] 1. Properties: This...

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Abstract

The invention provides a preparation method of a pharmaceutical composition Changrong Soft Capsule containing eucalyptol, limonene and Alpha-pinene, and relates particularly to a method for directly composing pharmaceutically active components eucalyptol, limonene and Alpha-pinene, a composition of the enteric coating of the Changrong Soft Capsule, and an one-step forming method.

Description

technical field [0001] The invention provides a preparation method of a pharmaceutical composition enteric-coated soft capsule containing eucalyptol, limonene and α-pinene. In particular, it relates to a method for direct combination of eucalyptol, limonene and α-pinene as active ingredients of medicines, a composition of enteric coating material for enteric soft capsules and a one-time molding method. Background technique [0002] Respiratory diseases are common and frequently-occurring diseases, and phlegm plays an important role, which has a good expectorant effect. After our in-depth research, we have invented an economical and environmentally friendly preparation method of enteric-coated soft capsules of this pharmaceutical composition. According to new investigations, there is no application of this preparation method in the production of enteric-coated soft capsules of this pharmaceutical composition at home and abroad at present. Contents of the invention [0003]...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/61A61K9/48A61K47/44A61P11/00A61K31/015
Inventor 黄志武
Owner BEIJING GRAND JOHAUM PHARMA CO LTD
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