Herbal composition for inflammatory disorders

A technology for inflammatory conditions, compositions, applied in the field of new herbal compositions, capable of addressing side effects, increased risk, etc.
CN101304756AInactive Publication Date: 2008-11-12PIRAMAL ENTERPRISES LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
PIRAMAL ENTERPRISES LTD
Publication Date
2008-11-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention relates to a novel herbal composition comprising an extract of flowering and fruiting heads of the plant, Sphaeranthus indicus. The said extract of Sphaeranthus indicus contains a compound, 3a-hydroxy-5a,9-dimethyl-3- methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1 ,2-b]furan-2-one (7- Hydroxy-4,1 1 (13)-eudesmadien-12,6-olide) (compound 1 ), as a bioactive marker. The invention also relates to a composition comprising 3a-hydroxy-5a,9-dimethyl- 3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1 ,2-b]furan-2-one (compound 1 ) as an active ingredient. The invention also relates to methods of manufacture of the said compositions. The invention also relates to methods of administration of the said compositions to a subject in need of treatment for an inflammatory disorder.; The invention also relates to tumor necrosis factor-a (TNF- a) and interleukin (IL-1 , IL-6, IL-8) inhibitory activity of the said compositions. The invention relates to inhibition of the expression of intercellular adhesion molecule 1 (ICAM-1 ), vascular-cell adhesion molecule 1 (VCAM-1 ), and E-Selectin by the said compositions. The said compositions may optionally contain at least one anti-inflammatory agent or can be used in combination with at least one anti- inflammatory agent.
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Description

technical field

[0001] The present invention relates to a novel herbal composition containing extracts of flowering head and fruiting head of the plant Sphaeranthus indicus. The present invention also relates to herbal compositions containing extracts obtained from the inflorescence heads and infructoses of S. tomentosa, comprising the compound 3a-hydroxy-5a,9-dimethyl-3-ylidene as a bioactive marker Methyl-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1,2-b]furan-2-one (7-hydroxy-4,11(13)- Eucalyptale-12,6-lactone (compound 1), and optionally one or more other active agents, for the effective treatment of inflammatory disorders. The present invention also relates to medicaments for the treatment of inflammatory disorders Compositions comprising 3a-hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho as active ingredient [1,2-b] furan-2-one (compound 1) and pharmaceutically acceptable carrier. The present invention also relates to the method for preparing said...

Claims

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