Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Herbal composition for inflammatory disorders

A technology for inflammatory conditions, compositions, applied in the field of new herbal compositions, capable of addressing side effects, increased risk, etc.

Inactive Publication Date: 2008-11-12
PIRAMAL ENTERPRISES LTD
View PDF0 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

To overcome the side effect problems of this series of treatments associated with prior art compositions (such as induction of allergic reactions, activation of latent tuberculosis, myelosuppression, increased risk of cancer and congestive heart disease), the inventors have prepared a potent Novel herbal composition against inflammation with anti-TNF-α, interleukins (IL-1, IL-6, IL-8) and anti-intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion Inhibitory activity of expression of molecule 1 (VCAM-1) and E-selectin

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Herbal composition for inflammatory disorders
  • Herbal composition for inflammatory disorders

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0088] Preparation of Methanol Extract from A. tomentosa

[0089] The dried flower heads and inflorescences (200 g) of A. tomentosa were crushed. The powdered material was extracted with methanol (2.5 L) at 60° C. for 3 hours with stirring. The extract was filtered under vacuum. Repeat this extraction process two more times. Extracts were combined and concentrated.

[0090] Yield: 23.29 g (11.65% w / w).

[0091] The extract of Example 1 was found to contain 6% of Compound 1 (described in Example 4) as estimated by HPTLC.

Embodiment 2

[0093] Preparation of Ethyl Acetate Extract from S. tomentosa

[0094] The dried flower heads and infructoses (350 g) of S. tomentosa were crushed. The powdered material was extracted with ethyl acetate (3 L) at 60°C for 3 hours with stirring. The extract was filtered under vacuum. Repeat this extraction process two more times. Extracts were combined and concentrated.

[0095] Yield: 19 g (9.5% w / w).

Embodiment 3

[0097] Preparation of water extract of Asteria tomentosa

[0098] The dried flower heads and inflorescences (200 g) of A. tomentosa were crushed. The powdered material was extracted with water (1.2 L) at 80°C-90°C for 3 hours with stirring. The extract was filtered under vacuum. Repeat this extraction process. The extracts were combined and concentrated to remove water. The crude extract was further dried by freeze drying.

[0099] Yield: 21 g (10.5% w / w).

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

This invention relates to a novel herbal composition comprising an extract of flowering and fruiting heads of the plant, Sphaeranthus indicus. The said extract of Sphaeranthus indicus contains a compound, 3a-hydroxy-5a,9-dimethyl-3- methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1 ,2-b]furan-2-one (7- Hydroxy-4,1 1 (13)-eudesmadien-12,6-olide) (compound 1 ), as a bioactive marker. The invention also relates to a composition comprising 3a-hydroxy-5a,9-dimethyl- 3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1 ,2-b]furan-2-one (compound 1 ) as an active ingredient. The invention also relates to methods of manufacture of the said compositions. The invention also relates to methods of administration of the said compositions to a subject in need of treatment for an inflammatory disorder.; The invention also relates to tumor necrosis factor-a (TNF- a) and interleukin (IL-1 , IL-6, IL-8) inhibitory activity of the said compositions. The invention relates to inhibition of the expression of intercellular adhesion molecule 1 (ICAM-1 ), vascular-cell adhesion molecule 1 (VCAM-1 ), and E-Selectin by the said compositions. The said compositions may optionally contain at least one anti-inflammatory agent or can be used in combination with at least one anti- inflammatory agent.

Description

technical field [0001] The present invention relates to a novel herbal composition containing extracts of flowering head and fruiting head of the plant Sphaeranthus indicus. The present invention also relates to herbal compositions containing extracts obtained from the inflorescence heads and infructoses of S. tomentosa, comprising the compound 3a-hydroxy-5a,9-dimethyl-3-ylidene as a bioactive marker Methyl-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1,2-b]furan-2-one (7-hydroxy-4,11(13)- Eucalyptale-12,6-lactone (compound 1), and optionally one or more other active agents, for the effective treatment of inflammatory disorders. The present invention also relates to medicaments for the treatment of inflammatory disorders Compositions comprising 3a-hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho as active ingredient [1,2-b] furan-2-one (compound 1) and pharmaceutically acceptable carrier. The present invention also relates to the method for preparing said...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61P29/00A61K133/00
Inventor 维贾伊·周汉阿希什·素他达南贾伊·沙普雷斯瓦蒂·巴尔-滕贝阿肖克·库马尔·甘戈帕德亚阿沙·库尔卡尼-阿尔梅达沙普那·豪希·帕里克
Owner PIRAMAL ENTERPRISES LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products