Application of echinacoside in preparing medicament for treating parkinsonism

A technology for echinacoside and Parkinson's disease, applied in the field of pharmaceuticals, can solve the problems of reducing and preventing the degeneration of dopaminergic neurons

Inactive Publication Date: 2008-12-03
ZHONGSHAN HOSPITAL FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Despite various treatments by neuroscientists, including levodopa preparations, all current studies suggest that the progressive reduction in degeneration of dopaminergic neurons cannot be stopped

Method used

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  • Application of echinacoside in preparing medicament for treating parkinsonism
  • Application of echinacoside in preparing medicament for treating parkinsonism
  • Application of echinacoside in preparing medicament for treating parkinsonism

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Example 1 Prepare tablets, pills, granules, syrups and ointments.

[0047] In addition to echinacoside, flavoring agents can be added as needed, or adjuvants such as vitamins, proteins and minerals that can enhance nutrition or immunity, or drugs that can act synergistically to treat Parkinson's disease. The ingredients of the tablets, pills, granules, syrups and ointments include:

[0048] Echinacoside 5%-90% (by weight)

[0049] Flavoring agent 0.1-1% (by weight)

[0050] Adjuvant Appropriate amount

[0051] The above-mentioned flavoring agent can be selected from α-cyclodextrin (α-CD), β-cyclodextrin (β-CD), N-LOK modified starch, sucrose, xylitol, high fructose, cyclamate, stevia and One or more of proteoglycans.

[0052] Adjuvants can be selected from vitamins or amino acids needed by the human body, such as vitamin B, vitamin C, lysine, glutamic acid, etc.

Embodiment 2

[0053] Example 2 Made into capsules. The capsule ingredients include:

[0054] Echinacoside 15%-30% (by weight)

[0055] Flavoring agent 0.5-10% (by weight)

[0056] The above-mentioned corrective agents mainly include: hydroxypropyl methylcellulose (HPMC), polyethylene glycol (PEG), acrylic resin, etc. Adjuvants can also be added, which can be selected from vitamins or amino acids needed by the human body, such as vitamin B, vitamin C, lysine, glutamic acid, etc.

Embodiment 3

[0057] Example 3 Made into injections and dropping pills. The injection and drop pills include:

[0058] Echinacoside 20%-30% (by weight)

[0059] Solvent amount

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PUM

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Abstract

The invention relates to an application of echinacoside in the preparation of drugs for treating Parkinson's disease. The invention discloses that echinacoside has a remarkable protective effect against the MMP+ mediated cell injury. The echinacoside can be used to prepare drugs for the treating Parkinson's disease and offers a new treatment for people with the Parkinson's disease.

Description

technical field [0001] The present invention relates to the application of echinacoside, in particular to the new application in the field of pharmacy. Background technique [0002] Cistanche (Hera CistaneMs) is a commonly used species in TCM tonic medicines, belonging to the genus Cistanche in the family of Ledanceae, and its medicinal products are its dried fleshy stems with scales. It was first recorded in "Shen Nong's Materia Medica" and listed as "top grade". It has the effects of nourishing the kidney and essence, moistening the intestines and laxative, and is mainly used to treat male impotence and female infertility. [0003] Echinacoside is a compound isolated and purified from Cistanche tubulosa. Previous studies have shown that echinacoside can increase the content of various central neurotransmitters, has a strong antioxidant effect, and can also prolong animal life and anti-aging effects. It is currently used in the treatment of anti-aging or senile dementia. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7028A61K9/08A61K9/20A61K9/48A61K9/10A61K9/06A61P25/16
Inventor 蔡定芳赵虹李文伟杨云柯唐红敏顾喜喜范越
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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