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Test systems for the analysis of polypeptides and cells adhering to silicones

An adhesive peptide, silicone technology, applied in the field of diagnostics, can solve the problem of not giving details and so on

Inactive Publication Date: 2009-02-18
威克免疫诊断与咨询公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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  • Test systems for the analysis of polypeptides and cells adhering to silicones
  • Test systems for the analysis of polypeptides and cells adhering to silicones
  • Test systems for the analysis of polypeptides and cells adhering to silicones

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example 1

[0154] Example 1: Construction of an in vitro system for screening proteins attached to different silicone types in vivo

[0155] Principles of protein preparation and analysis such as image 3 shown.

[0156] 1. Proteins eluted from ex vivo

[0157] The inventors of the present invention analyzed the proteins deposited on SMIs explanted from women experiencing complications following breast augmentation for cosmetic reasons. Thirteen explanted SMIs were obtained from the Clinic for Plastic and Reconstructive Surgery at the Medical University of Innsbruck (MUI, Innsbruck, Austria). Nine SMIs were gel and 4 were saline filled. Eleven SMIs were rough and 2 were smooth surfaces. Only intact implants (ie, no silicone "gel flow") were considered for analysis. Place them under sterile conditions immediately after surgery. The fibrotic capsule was removed in the operating room and the SMIs were transferred to the laboratory in phosphate-buffered saline (PBS, pH 7.2) supplemen...

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Abstract

The present invention relates in general to the field of diagnostics, namely to test systems for polypeptides in respect to silicone. More precisely, the present invention, in one embodiment thereof, concerns test systems for identifying and analysing polypeptides adhering to silicone. Furthermore, the present invention relates to newly identified polypeptides adhering to silicone and to respective uses of such proteins, e.g., in test systems for detecting a response reaction of a mammal to a silicone.

Description

technical field [0001] The present invention relates generally to the field of diagnostics, ie to test systems for polypeptides related to silicones. More precisely, the present invention in one of its embodiments relates to a test system for the identification and analysis of polypeptides adhered to silicone. Furthermore, the present invention relates to newly identified silicone-adhering polypeptides and uses of such proteins, for example in test systems for detecting a response reaction of a mammal to a silicone Applications. Background technique [0002] Dimethicone polymer, also known as "silicone", is the most widely utilized inorganic biomaterial in medical practice because of the biocompatibility it exhibits. It is used in a wide variety of applications such as medical tubing, syringe lubricants, coatings for active medical devices such as bypass devices and cochlear implants, and in the production of everything from joint replacements and eyeglass lenses to ventri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/50G01N33/68
CPCG01N33/5005G01N33/6803A61P43/00
Inventor 乔治·威克尼古劳斯·威克亚历山大·巴奇科维奇
Owner 威克免疫诊断与咨询公司
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