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Preparation method of soft-capsule of saw palmetto fruit extract

The technology of extract and saw palmetto is applied in the field of preparation of saw palmetto fruit extract soft capsules, and can solve the problems of difficult long-term uniformity and stability of quality, prolonged disintegration time of soft capsules, and many reductions in effective components, and the like. Increased social and economic benefits, accurate dosage, and reduced special odors

Active Publication Date: 2011-03-23
JIANGSU SHENLONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, Saw palmetto fruit extract has a strong special smell. Although the operators have certain protective measures during the production process, the special smell will cause strong discomfort; A series of problems; after being prepared into soft capsules, the special smell still exists, which may affect patients' compliance
And the disintegration time of the soft capsule is prolonged after being placed for a long time
Soft capsules prepared from saw palmetto fruit extracts are usually difficult to ensure long-term uniform and stable quality, and the active ingredients usually drop more at the end of the validity period, which leads to the need to increase the dosage of the main drug when the product is produced, which greatly increases the production cost. Reduced economic benefits

Method used

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  • Preparation method of soft-capsule of saw palmetto fruit extract
  • Preparation method of soft-capsule of saw palmetto fruit extract
  • Preparation method of soft-capsule of saw palmetto fruit extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033]

[0034] Capsule rubber material composition weight ratio

[0035] Water: Glycerin: Gelatin: β-cyclodextrin = 1:0.8:0.7:0.04

[0036] Preparation Process:

[0037] Heat polyethylene glycol 4000 to 60°C until it is completely melted, add the prescribed amount of saw palmetto fruit extract, stir until completely dissolved, rapidly cool under stirring conditions, and place it at -4°C for 24 hours into brittle and brittle matter, crushed into fine powder to obtain saw palmetto fruit extract-polyethylene glycol solid dispersion inclusion compound, add the solid dispersion inclusion compound to the prescription amount of peanut oil, and add the prescription amount of hydroxypropyl cellulose at the same time Suspension, benzyl p-hydroxybenzoate and beeswax, stirred well to obtain a uniform and stable suspension. Add the suspension and capsule rubber materials (6880g of water, 5504g of glycerin, 4816g of gelatin, and 275g of β-cyclodextrin) into a soft capsule press, press...

Embodiment 2

[0039]

[0040] Capsule rubber material composition weight ratio

[0041] Water: Glycerin: Gelatin: β-cyclodextrin = 1:0.6:0.5:0.02

[0042] Preparation Process:

[0043]Heat polyethylene glycol 1500 to 55°C until it is completely melted, add the prescribed amount of saw palmetto fruit extract, stir until completely dissolved, rapidly cool under stirring conditions, and place it at -4°C for 24 hours into brittle and brittle matter, crushed into fine powder to obtain saw palmetto fruit extract-polyethylene glycol solid dispersion inclusion compound, add the solid dispersion inclusion compound to the prescription amount of peanut oil, and add the prescription amount of hydroxypropyl cellulose at the same time Suspension, benzyl p-hydroxybenzoate and beeswax, stirred well to obtain a uniform and stable suspension. Add the suspension and capsule rubber materials (8000g of water, 4800g of glycerin, 4000g of gelatin, and 160g of β-cyclodextrin) into a soft capsule press, press ...

Embodiment 3

[0045]

[0046]

[0047] Capsule rubber material composition weight ratio

[0048] Water: Glycerin: Gelatin: β-cyclodextrin = 1:0.6:0.5:0.03

[0049] Preparation Process:

[0050] Heat polyethylene glycol 4000 to 60°C until it is completely melted, add the prescribed amount of saw palmetto fruit extract, stir until it is completely dissolved, rapidly cool it under stirring conditions, and place it at 0°C for 24 hours to make it The brittle and fragile matter is crushed into fine powder to obtain the saw palmetto fruit extract-polyethylene glycol solid dispersion inclusion compound, and the solid dispersion inclusion compound is added to the prescription amount of peanut oil, and the prescription amount of hydroxypropyl cellulose is added at the same time , benzyl p-hydroxybenzoate and beeswax, fully stirred to obtain a uniform and stable suspension. Add the suspension and capsule rubber materials (8000g of water, 4800g of glycerin, 4000g of gelatin, and 240g of β-cyclo...

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Abstract

The invention discloses a preparing method for sawpalmetto fruit extractive soft capsule, which includes medicine liquid preparation and the capsule skin material preparation. The preparing method is characterized in that the sawpalmetto fruit extractive can be dispersed in polyethyleneglycol in the form of molecule through preparing the sawpalmetto fruit extractive polyethyleneglycol solid dispersion so as to reach the effect of concealing odor and improving stability. In addition, the capsule skin is made of mixture of glutin, glycerin, water and cyclodextrin ramification so as to ensure that the soft capsule can still keep disintegration time as the same to the original condition after being placed for long time.

Description

technical field [0001] The invention relates to the technical field of medicine and pharmacy, in particular to a preparation method of saw palmetto fruit extract soft capsules. Background technique [0002] Saw palmetto fruit extract soft capsule is a natural plant preparation prepared from the ripe fruit of the palm shrub Saw palmetto, which grows in the southeastern United States and the coastal sandy plains of the Gulf of Mexico, through supercritical carbon dioxide extraction. into soft capsules. The main ingredients are various free fatty acids, sterols and flavonoids. This pure plant extract preparation is clinically used to treat benign prostatic hyperplasia and prostatitis. It has many advantages such as definite curative effect, good tolerance, less adverse reactions, and no impact on sexual function. It has been widely used in Europe and the United States. [0003] The pharmacological effect of saw palmetto fruit extract is to reduce the production of dihydrotest...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K36/889A61P13/08A61K131/00
Inventor 胡传良徐成秦勇金春周自桂景瑞
Owner JIANGSU SHENLONG PHARMA